SynthesisFrontiers in pharmacology2025
Efficacy and safety of commercial Chinese polyherbal preparation combined with oxaliplatin-based chemotherapy for gastric cancer: a systematic review and network meta-analysis.
Synthesis in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Modulation of the gut microbiota by traditional Chinese medicine to attenuate chemotherapy-induced toxicity in gastric cancer: a review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Review
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9 authors.
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Abstract
Objective: To evaluate the efficacy, safety, and quality of evidence for commercial Chinese polyherbal preparations (CCPPs) in combination with oxaliplatin-based chemotherapy (OX) for gastric cancer (GC). Methods: We searched six databases for randomized controlled trials (RCTs) comparing CCPPs plus OX to other active treatments for GC. The risk of bias was assessed using a modified version of Cochrane risk of bias tool. A frequentist network meta-analysis using a random-effects model was performed to estimate the relative effectiveness between treatments. We used GRADE to assess the certainty of evidence, to categories the interventions, and to present the findings. Results: One-hundred-and-eighty-nine RCTs involving 15,320 participants that reported 27 CCPPs were identified. Moderate to high certainty evidence showed that Compound Mylabris preparations (Disease Control Rate (DCR): 1.51, 1.13-2.03) is among the most effective CCPPs for improving DCR, while Kangai Injection (objective response rate (ORR): 1.40, 1.28 to 1.77; quality of life (QoL): 1.46, 1.11-1.94), Huachansu preparations (ORR: 1.28, 1.15-1.43), Ya Dan Zi Oil Emulsion Injection (QoL: RR 1.26, 1.06-1.51), Aidi Injection (QoL: 1.30, 1.13-1.50), Lentinan (QoL: 1.27, 1.05-1.54), and Yangzheng Xiaoji Capsules (ORR: 1.36, 1.05-1.77) showed intermediate efficacy for ORR and QoL. Regarding immune function improvement, with moderate to high certainty evidence, Shenmai Injection (CD3 Conclusion: No CCPP was optimal for all endpoints, Compound Mylabris showed superior tumor response, and Kangai Injection offered the most favorable risk-benefit profile, providing broad efficacy and statistically significantly reducing AEs. The choice of adjuvant CCPP should be individualized based on specific therapeutic priorities, balancing efficacy and safety. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42025646173.
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