Enantioselective desymmetrization strategy of prochiral 1,3-diols in natural product synthesis.

Lihua Wei, Rui Yang, Zhifeng Shi, Zhiqiang Ma

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Review in Beilstein journal of organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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4 authors.

Lihua Wei *Key Lab of Functional Molecular Engineering of Guangdong Province, School of Chemistry & Chemical Engineering, South China University of Technology, Guangzhou 510641, P. R. China.

Rui Yang *Key Lab of Functional Molecular Engineering of Guangdong Province, School of Chemistry & Chemical Engineering, South China University of Technology, Guangzhou 510641, P. R. China.

Zhifeng ShiMedical Devices Research and Testing Center, South China University of Technology, Guangzhou 510006, P. R. China.

Zhiqiang MaKey Lab of Functional Molecular Engineering of Guangdong Province, School of Chemistry & Chemical Engineering, South China University of Technology, Guangzhou 510641, P. R. China.ORCID https://orcid.org/0000-0002-3983-6636

Funding

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6 · The paper itself

Abstract

Enantioselective desymmetrization is employed as a powerful tool for the creation of chiral centers. Within this scope, the enantioselective desymmetrization of prochiral 1,3-diols, which generates chiral centers by enantioselective functionalization of one hydroxy group, offers beneficial procedures for accessing diverse structural motifs. In this review, we highlight a curated compilation of publications, focusing on the applications of enantioselective desymmetrization of prochiral 1,3-diols in the synthesis of natural products and biologically active molecules. Based on the reaction types, three strategies are discussed: enzymatic acylation, transition-metal-catalyzed acylation, and local desymmetrization.

Indexed as

1,3-diolsasymmetric synthesisdesymmetrizationnatural producttotal synthesis

Identifiers

PMID40994629

DOI10.3762/bjoc.21.151

PMCPMC12456081

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