ArticlebioRxiv : the preprint server for biology2025
An optogenetic assay of
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
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Abstract
Background: Over fifty million people worldwide currently live with neurodegenerative diseases, many of which are the result of pathogenic gene variants. Genetically malleable model organisms provide an avenue for research into the genetic bases of these diseases, and the large motor neurons of fruit fly larvae provide a test bed for investigating neuronal mechanisms impacted by pathogenic gene variants. However, it is challenging to collect information from these neurons under physiological conditions as they terminate on muscle fibers that are perpetually contracting - driven by motor neuron burst-firing. New Method: As a test of Results: We describe the assembly of an apparatus to systematically activate motor-neurons in Comparison with Existing Methods: This Conclusions: We demonstrated that
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.