Rapid osteointegration with a strontium-containing hydroxyapatite coating on tantalum by activating Itga6-PI3K/AKT signaling pathway.

Xi Wang, Tiantian Chen, Peng Pan, Chundong Jiang, Wentao Liu, Xu Yan

Abstract read

In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xi WangDepartment of Emergency and Oral Medicine, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, China.

Tiantian ChenShenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China.

Peng PanShenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China.

Chundong JiangChongqing Institute of Mesoscopic Medical Porous Materials, Chongqing, China.

Wentao LiuShenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China.

Xu YanThe VIP Department, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Owing to its excellent biocompatibility, tantalum has the potential to replace titanium as a new mainstream bone-repair material. However, it was recognized as an inert metal. Therefore, it is necessary to improve the bioactivity of tantalum through surface modification to achieve more stable osseointegration. The key to designing bone repair materials is to imitate the physical structure and chemical composition of natural bone. In this study, a microscale strontium-containing hydroxyapatite (Sr + HA) coating was loaded onto a tantalum surface using a hydrothermal method, which improved the protein adsorption ability and hydrophilicity of tantalum. The incorporation of Sr also promoted the release of Sr

Indexed as

HydroxyapatiteOsseointegrationStrontiumTantalum

Identifiers

PMID40994622

DOI10.1016/j.mtbio.2025.102284

PMCPMC12454878

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.