Evidence map›Paper›PMID 40994602›Full record

ArticleInternational journal of ophthalmology2025

Corneal endothelial characteristics and biometric parameters in microcornea.

Xiang-Zheng Zhang, Li Pei, Jia-Ning Shi, Xi Lu, Ran-Yi Ding, Xiao-Wei Zhong, Xin Wang, Du-Lei Zou, Wei-Yun Shi, Can Zhao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiang-Zheng ZhangShandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, Shandong Province, China.
Li PeiEye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan 250021, Shandong Province, China.
Jia-Ning ShiEye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan 250021, Shandong Province, China.
Xi LuEye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan 250021, Shandong Province, China.
Ran-Yi DingEye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan 250021, Shandong Province, China.
Xiao-Wei ZhongEye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan 250021, Shandong Province, China.
Xin WangEye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan 250021, Shandong Province, China.
Du-Lei ZouShandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, Shandong Province, China.
Wei-Yun ShiEye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan 250021, Shandong Province, China.
Can ZhaoEye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan 250021, Shandong Province, China.
Ting WangEye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan 250021, Shandong Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo assess the corneal biometric parameters and endothelial cell characteristics in microcornea patients, and exploring their correlations.

methodsThis cross-sectional study included 28 patients of microcornea with uveal coloboma (MCUC), 13 patients of microcornea without coloboma (MCNC), and 30 age-matched healthy individuals (the control group). Corneal biometric parameters such as axial length (AL), anterior chamber depth (ACD), and white-to-white corneal diameter (WTW) were measured using the IOL Master. The corneal endothelial cell density (ECD), percentage of hexagonal cells (6A), average cell area (AVE), maximum cell area (MAX), minimum cell area (MIN), cell area standard deviation (SD), and coefficient of variation (CV) were collected by specular microscopy.

resultsThis study included MCUC and MCNC patients with age- and sex-matched controls. All patients exhibited significantly reduced WTW (MCUC: 8.51±0.71 mm; MCNC: 9.08±0.42 mm) and worse logMAR BCVA (MCUC 0.62±0.43; MCNC 0.46±0.28) compared to controls (both

conclusionThe corneal ECD and 6A are increased, while the CV is decreased in patients with microcornea, particularly in those accompanied by uveal coloboma. The ECD and morphology demonstrate close correlations with the WTW and ACD.

Indexed as

anterior chamber depthcorneal biometric parameterscorneal endothelial cellmicrocorneauveal coloboma

Identifiers

PMID40994602
PMCPMC12454012

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.