ArticleInternational journal of ophthalmology2025
Single subconjunctival injection formulation with a 5-fluorouracil-poly(lactic) acid controlled-release system for glaucoma filtration surgery.
Article in International journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
aimTo develop a 5-fluorouracil (5-FU) mesoporous poly(lactic) acid (PLA) delivery system for glaucoma filtration surgery suitable for a single subconjunctival implantation.
methodsThe 5-FU was infiltration-loaded into mesoporous PLA.
resultsVarious drug formulations were tested, and two 5-FU-PLA tablets, namely 1.5P15 (5-FU 1.5 mg+PLA 15 000 Da) and 2.5P15 (5-FU 2.5 mg+PLA 15 000 Da), had the most suitable release profiles
conclusionThe tested 5-FU-PLA tablets provide a sustained release of 5-FU, which may be used for a single subconjunctival implantation to inhibit proliferation after filtration surgery.
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