ReviewEuropean urology open science2025
Impact of PARP Inhibitors on Health-related Quality of Life in Patients with Metastatic Castration-resistant Prostate Cancer: A Systematic Review and Meta-analysis.
Review in European urology open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Trial
- Polydopamine-Coated Surfaces Promote Adhesion, Migration, Proliferation, Chemoresistance, Stemness, and Epithelial-Mesenchymal Transition of Human Prostate Cancer Cell Lines In Vitro via Integrin αInternational journal of molecular sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and objective: PARP inhibitor (PARPi) agents, alone or in combination with antiandrogens, are considered a standard of care for patients with metastatic castration-resistant prostate cancer (mCRPC). This meta-analysis evaluates the impact of PARPi agents on health-related quality of life (HRQoL) using data from prospective trials. Methods: In this prospectively registered systematic review and meta-analysis (PROSPERO: CRD420251011282), we searched the MEDLINE, Embase, and Web of Science databases in March 2025 for prospective trials assessing the impact of PARPi on patient HRQoL in mCRPC. Results for the mean differences (MD) in Functional Assessment of Cancer Therapy-Prostate (FACT-P) total scores at early and late time points were pooled using a random-effects model. Key findings and limitations: Reports for seven prospective trials (2861 patients) were included. The PROfound trial ( Conclusions and clinical implications: We observed no statistically or clinically meaningful deterioration in HRQoL with PARPi treatment in patients with mCRPC, with one study suggesting a potential benefit. Predefined thresholds may not capture the individual and complex nature of HRQoL in the palliative mCRPC setting, where even modest changes can have important clinical and personal significance, which underscores the importance of nuanced interpretation of HRQoL data in guiding treatment decisions. Patient summary: We did not find evidence that drugs called PARP inhibitors have a negative effect on health-related quality of life (HRQoL) for men with advanced prostate cancer. However, the current tools used to measure HRQoL may not fully reflect the individual and complex experiences of patients receiving palliative treatment for their cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.