ArticleaBIOTECH2025
BMI1s interact with condensin complexes to regulate chromatin 3D structure and gene expression in
Article in aBIOTECH, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The accurate chromatin states are essential for maintaining genome integrity and ensuring the normal transcription of genes. Polycomb group (PcG) proteins regulate chromatin states not only by modifying the chromatin, but also by influencing the chromatin three-dimensional (3D) structure. The core components of Polycomb repressive complex 1 (PRC1), B LYMPHOMA MOLONEY MURINE LEUKEMIA VIRUS INSERTION REGION 1 HOMOLOG 1A/B/C (BMI1s), have been reported to maintain the compartment domains (CDs) generally, but the mechanism by which they function remains elusive. Here, we reveal that condensin complexes, whose function are related to chromatin or chromosome, can interact with BMI1s. Removal of condensin I or II also leads to global impairment of CDs. The significantly impaired CDs in Supplementary Information: The online version contains supplementary material available at 10.1007/s42994-025-00202-x.
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