Evidence map›Paper›PMID 40994406›Full record

ArticleHistology and histopathology2026

Unraveling key molecules mediating the mechanisms of YAP deletion or inhibition in liver fibrosis regression through a multi-omics approach.

Siyuan Wang, Shihui Liu, Hejing Ruan, Yuzhe Cheng, Yan Qiao, Jiawei Wang, Xiaojun Liu, Chuanmiao Liu, Wen Zhao

Abstract read
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In one paragraph

Article in Histology and histopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Nutrients · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Siyuan WangDepartment of Infectious Diseases, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Shihui LiuDepartment of Infectious Diseases, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Hejing RuanDepartment of Infectious Diseases, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Yuzhe ChengBengbu Medical University, Bengbu, China.
Yan QiaoDepartment of Infectious Diseases, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Jiawei WangDepartment of Medical Engineering, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Xiaojun LiuDepartment of Infectious Diseases, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Chuanmiao LiuCore cooperative unit of the National Clinical Research Center for Infectious Diseases, Shenzen, China.
Wen ZhaoCore cooperative unit of the National Clinical Research Center for Infectious Diseases, Shenzen, China.

Funding

2024 Science and Technology Program of Bengbu Medical University 2024byzd093Anhui University Student Innovation and Entrepreneurship Training Program S202410367104Health Research Program of Anhui Province AHWJ2022b069
6 · The paper itself

Abstract

backgroundThis study aimed to identify key molecules that potentially mediate the mechanisms by which YAP deletion or inhibition attenuates liver fibrosis. MATERIALS AND

methodsC57BL/6 mice were divided into four groups: control, carbon tetrachloride (CCl

resultsIn comparison with the CCl

conclusionsThis study identified HSP27, HSP70, p62, and MFGE8 as crucial YAP-related molecules involved in liver fibrosis.

Indexed as

Adaptor Proteins, Signal TransducingLiver CirrhosisTranscription FactorsAnimalsHumansLiverMaleMiceMice, Inbred C57BLMice, KnockoutMultiomicsProteomicsYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingTranscription FactorsYAP1 protein, humanYap1 protein, mouseYAP-Signaling Proteins

Identifiers

PMID40994406

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.