Evidence map›Paper›PMID 40994280›Full record

ArticleACS infectious diseases2025

Discovery and Characterization of Cell-Permeable Inhibitors of

Carolina M C Catta-Preta, Priscila Zonzini Ramos, Juliana B T Carnielli, Stanley N S Vasconcelos, Adam Dowle, Rebeka C Fanti, Caio V Dos Reis, Adriano Cappellazzo Coelho, Katlin B Massirer, Jeremy C Mottram and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Carolina M C Catta-PretaCentro de Química Medicinal (CQMED), Centro de Biologia Molecular e Engenharia Genética (CBMEG), Universidade Estadual de Campinas, UNICAMP, 13083-886 Campinas, SP, Brazil.
Priscila Zonzini RamosCentro de Química Medicinal (CQMED), Centro de Biologia Molecular e Engenharia Genética (CBMEG), Universidade Estadual de Campinas, UNICAMP, 13083-886 Campinas, SP, Brazil.
Juliana B T CarnielliYork Biomedical Research Institute, Department of Biology, University of York, York YO10 5DD, United Kingdom.
Stanley N S VasconcelosCentro de Química Medicinal (CQMED), Centro de Biologia Molecular e Engenharia Genética (CBMEG), Universidade Estadual de Campinas, UNICAMP, 13083-886 Campinas, SP, Brazil.
Adam DowleBioscience Technology Facility, Department of Biology, University of York, York YO10 5DD, United Kingdom.ORCID 0000-0002-6501-5444
Rebeka C FantiCentro de Química Medicinal (CQMED), Centro de Biologia Molecular e Engenharia Genética (CBMEG), Universidade Estadual de Campinas, UNICAMP, 13083-886 Campinas, SP, Brazil.
Caio V Dos ReisCentro de Química Medicinal (CQMED), Centro de Biologia Molecular e Engenharia Genética (CBMEG), Universidade Estadual de Campinas, UNICAMP, 13083-886 Campinas, SP, Brazil.
Adriano Cappellazzo CoelhoDepartamento de Biologia Animal, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas 13083-862, Brazil.
Katlin B MassirerCentro de Química Medicinal (CQMED), Centro de Biologia Molecular e Engenharia Genética (CBMEG), Universidade Estadual de Campinas, UNICAMP, 13083-886 Campinas, SP, Brazil.ORCID 0000-0001-6390-2560
Jeremy C MottramYork Biomedical Research Institute, Department of Biology, University of York, York YO10 5DD, United Kingdom.ORCID 0000-0001-5574-3766
Rafael M CouñagoCentro de Química Medicinal (CQMED), Centro de Biologia Molecular e Engenharia Genética (CBMEG), Universidade Estadual de Campinas, UNICAMP, 13083-886 Campinas, SP, Brazil.ORCID 0000-0003-1847-5090

Funding

Wellcome Trust
6 · The paper itself

Abstract

Leishmaniasis is a neglected tropical disease with limited treatment options and significant unmet medical need. Here, we report the development of a bioluminescence resonance energy transfer (BRET)-based target engagement assay in live cells to identify and validate cell-permeable, ATP-competitive inhibitors of

Indexed as

Antiprotozoal AgentsLeishmania mexicanaProtein Kinase InhibitorsProtein Serine-Threonine KinasesProtein-Tyrosine KinasesProtozoan ProteinsAnimalsDrug DiscoveryHumansMacrophagesMiceAntiprotozoal AgentsClk dual-specificity kinasesProtein Kinase InhibitorsProtein Serine-Threonine KinasesProtein-Tyrosine KinasesProtozoan Proteinsdrug discoveryinfectious diseaseskinase inhibitorleishmaniasisprotein kinasetarget engagement

Identifiers

PMID40994280
PMCPMC7619385

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.