SynthesisAnnals of medicine2025
Efficacy and toxicity of treatment of smoldering multiple myeloma: a systematic review and meta-analysis.
Synthesis in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- RNA-Based Therapeutic Strategies in Multiple Myeloma: From Molecular Targets to Delivery and Clinical Translation.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSmoldering multiple myeloma (SMM) is a slowly progressive, asymptomatic plasma cell disorder. This meta-analysis evaluated the efficacy and safety of novel agent-based therapies for SMM, particularly high-risk patients.
methodsPubMed, Embase, Web of Science, Ovid MEDLINE, Scopus and ClinicalTrials.gov were searched for randomized controlled trials (RCTs) and non-randomized studies from 2003 to 2024.
resultsNineteen studies were included, comprising 5 RCTs and 14 non-randomized, single-arm trials. These studies involved a total of 1217 patients. Pooled analysis of intervention groups showed progression-free survival (PFS) and overall survival (OS) rate at 12 months of 94% (95% CI, 89%-98%) and 99% (95% CI, 97%-100%), respectively. The overall response rate (ORR) was 64% (95% CI, 50%-77%), and the complete response rate (CRR) was 12% (95% CI, 3%-25%). Minimal residual disease (MRD) negativity rate was 62% (95% CI, 42%-81%), and grade 3-4 adverse events (AEs) rate was 36% (95% CI, 30%-43%). As a comparison, we pooled data from the control groups of 5 RCTs, showing that PFS and OS rate-12m were 76% and 97%, respectively, with 0% CRR, 0% ORR and 25% grade 3-4 AEs. Subgroup analysis revealed high-risk SMM patients achieved higher PFS rate -12 m (97% vs. 91%), ORR (77% vs. 53%) and CRR (24% vs. 5%) compared to all SMM patients, with similar OS rate-12m (99% vs. 99%) and AEs rates (38% vs. 34%).
conclusionEarly intervention may delay progression and improve clinical responses, especially in high-risk SMM. However, adverse events (AEs) warrant caution. More well-designed RCTs are needed to confirm our findings.
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