Evidence map›Paper›PMID 40994090›Full record

ArticleAmerican journal of clinical pathology2025

Impact of the Genius Digital Diagnostics System on workflow and accuracy compared with the ThinPrep Imaging System for review of ThinPrep Papanicolaou tests.

Kathleen M Murphy, Kristina Weatherhead, Carrie Chenault, Chinh Nguyen, Kari Sefcik, Sarah Harrington, Kasey Johnson, Yan Lemeshev

Abstract readComparative Study
In one paragraph

Article in American journal of clinical pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kathleen M MurphyProPath, A Sonic Healthcare Anatomic Pathology Practice, Dallas, TX, United States.
Kristina WeatherheadProPath, A Sonic Healthcare Anatomic Pathology Practice, Dallas, TX, United States.
Carrie ChenaultProPath, A Sonic Healthcare Anatomic Pathology Practice, Dallas, TX, United States.
Chinh NguyenProPath, A Sonic Healthcare Anatomic Pathology Practice, Dallas, TX, United States.
Kari SefcikProPath, A Sonic Healthcare Anatomic Pathology Practice, Dallas, TX, United States.
Sarah HarringtonScientific Affairs Department, Hologic, Inc, Marlborough, MA, United States.
Kasey JohnsonScientific Affairs Department, Hologic, Inc, Marlborough, MA, United States.
Yan LemeshevProPath, A Sonic Healthcare Anatomic Pathology Practice, Dallas, TX, United States.

Funding

Hologic, Inc
6 · The paper itself

Abstract

objectiveIn this study, we compared the workflow of the Genius Digital Diagnostics System (Hologic, Inc) with our current workflow based on the ThinPrep Imaging System (Hologic, Inc) to assess potential efficiencies associated with digitalization of Papanicolaou screening.

methodsEach step of the current workflow (glass slide movement and slide review) and the experimental workflow were documented. Substantial workflow efficiencies were associated with the reduction of glass slide movement observed with the experimental workflow of the Genius system compared with the ThinPrep system.

resultsThe ThinPrep-based workflow required more than 5 hours of hands-on time at specific synchronized times throughout the day, whereas the hands-on time of the experimental Genius Digital Diagnostics System was just over an hour and allowed glass movement at flexible times. In addition to these workflow efficiencies, the Genius Digital Diagnostics System resulted in much shorter review times (70.1 seconds) than the ThinPrep Imaging system (138.0 seconds) while maintaining similar agreement to the sign-out diagnosis.

conclusionsThis study demonstrated that implementing a Genius Dx-based workflow may result in substantial efficiency gains, which can mitigate workforce shortages and improve turnaround time without compromising screening accuracy.

Indexed as

Papanicolaou TestUterine Cervical NeoplasmsVaginal SmearsWorkflowFemaleHumansartificial intelligencecervical cancercytologycytopathologydigital cytologydigital pathologyGenius Digital Diagnostics Systemlab efficiencyPapanicolaou testworkflow

Identifiers

PMID40994090
PMCPMC12629871

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.