ArticleNeuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition2025
Hippocampal volume moderates the association between cerebrospinal fluid growth-associated protein 43 and episodic memory performance in older adults.
Article in Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study examined the relationships between fluid and imaging biomarkers associated with memory (cerebrospinal fluid growth-associated protein 43 [CSF GAP-43] and hippocampal volume) and episodic memory performance in 586 older adults (mean age = 72.6 years, SD = 7.2) from the Alzheimer's Disease Neuroimaging Initiative who completed CSF collection, Magnetic Resonance Imaging, and neuropsychological testing. Hierarchical linear regressions assessed whether FreeSurfer-derived total hippocampal volume or hippocampal subfield volume (subiculum, presubiculum, dentate gyrus, CA1) moderated the association between GAP-43 and episodic memory performance. GAP-43 and hippocampal volume were independently associated with episodic memory performance. Greater GAP-43 was associated with lower episodic memory performance in older adults with average or below-average (-1 SD) total and subfield (subiculum, presubiculum, dentate gyrus) hippocampal volume. No associations were observed in participants with above-average (+1 SD) volume. These findings suggest that GAP-43 may serve as a biomarker correlate of episodic memory impairment in those with average or below-average hippocampal volume.
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