ReviewAnti-inflammatory & anti-allergy agents in medicinal chemistry2025
Analytical Techniques for the Quantification and Validation of Resveratrol: A Review.
Review in Anti-inflammatory & anti-allergy agents in medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Salt-saturated supramolecular solvent-assisted dispersive liquid-liquid microextraction for the efficient enrichment and determination of resveratrol in water and grape juice.BMC chemistry · 2026Article
- Molecular and Analytical Understanding of Resveratrol Interactions for Advanced Biotechnological Applications.Molecules (Basel, Switzerland) · 2026Review
- Leveraging agricultural waste manipulation using a novel resveratrol-producing endophytic fungus,Frontiers in bioengineering and biotechnology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTrans-resveratrol is a bioactive polyphenol that has been widely studied for its antioxidant, anti-inflammatory, and chemoprotective properties. It holds promise in pharmaceutical and nutraceutical formulations but is limited by poor bioavailability and stability.
methodsThis review synthesizes validated analytical methods for quantifying trans-resveratrol across various matrices. A comprehensive literature search (2000-2024) was conducted using PubMed, Scopus, and Google Scholar, focusing on RP-HPLC, HPTLC, GC, and UV spectroscopy. Method validation follows ICH guidelines. and nutraceutical formulations but is limited by poor bioavailability and stability.
resultsThirty-seven validated analytical methods were reviewed. RP-HPLC using C18 columns with acetonitrile-water mobile phases dominated the literature. The most sensitive technique identified was LC-MS/MS (LOD = 0.001 μg/mL), particularly effective in biological samples. Matrix types included wine, serum, and nanoparticle formulations. and nutraceutical formulations but is limited by poor bioavailability and stability. DISCUSSION: RP-HPLC and LC-MS/MS have emerged as robust techniques for resveratrol quantification due to their sensitivity and specificity. Emerging tools like biosensors and UPLC offer rapid analysis with lower solvent consumption. Challenges such as isomerization, photodegradation, and matrix interferences necessitate stringent sample-handling protocols. and nutraceutical formulations but is limited by poor bioavailability and stability.
conclusionAdvanced chromatographic methods, especially RP-HPLC and LC-MS/MS, are essential for the reliable quantification of trans-resveratrol. Future research should focus on analytical standardization and the development of novel delivery systems to enhance resveratrol's pharmacokinetic profile.
Indexed as
Identifiers
40993954What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.