Evidence map›Paper›PMID 40993891›Full record

ReviewInternational ophthalmology clinics2025

Applications of New Generation Sequencing (NGS) in Ocular Oncology.

Mizuki Tagami, Shigeru Honda

Abstract readReview
In one paragraph

Review in International ophthalmology clinics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mizuki TagamiDepartment of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.ORCID 0000-0002-8771-7252
Shigeru Honda

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Next-generation sequencing (NGS) has revolutionized cancer genomics, offering unparalleled insights into the molecular landscape of various malignancies, including ocular cancers. This review explores the role of NGS in ocular oncology, highlighting its impact on understanding genetic alterations, identifying biomarkers, and advancing personalized treatment approaches. Key applications in uveal melanoma, retinoblastoma, and other ocular tumors, including ocular adnexa lymphoma and IgG4-related ophthalmic disease are discussed, along with the challenges and future directions in the field. As sequencing technologies continue to evolve, integrating NGS into clinical practice promises to enhance early diagnosis, risk assessment, and therapeutic strategies in ocular oncology.

Indexed as

Eye NeoplasmsHigh-Throughput Nucleotide SequencingBiomarkers, TumorGenomicsHumansBiomarkers, TumorIgG4-related ophthalmic disease (IgG4-ROD)immunohistochemistrymachine learningorbital MALT lymphomaprincipal component analysisRNA-seqSTING

Identifiers

PMID40993891
PMCPMC12459143

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.