SynthesisSystematic reviews2025
Effects of vitamin D supplements on bone metabolism in kidney transplant recipients: a systematic review and meta-analysis.
Synthesis in Systematic reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Letter to the Editor: Bone disease in kidney transplant: don't forget about osteomalacia: a case report and literature review.International urology and nephrology · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVitamin D has been reported to decrease parathyroid hormone (PTH), reduce bone loss, and promote calcium absorption. However, its effects on bone metabolism in kidney transplant recipients (KTRs) remain controversial. This review aimed to analyze the effects of vitamin D supplements on bone metabolism in KTRs.
methodsWe searched PubMed, EMBASE, Web of Science, and the Cochrane Library from inception through September 30, 2023, for randomized controlled trials (RCTs) on the effect of vitamin D on bone metabolism after kidney transplantation. We also searched the reference lists of systematic reviews and included studies. The outcomes were expressed using relative risk (RR) or standardized mean difference (SMD) with the corresponding 95% confidence interval (CI).
resultsFourteen studies involving a total of 985 KTRs were included in this analysis. The treatments consisted vitamin D supplementation at various doses and types. The duration of follow-up ranged from 3 to 12 months. More than half of the 14 studies (n = 8) had an overall high risk of bias, as they had at least one high-risk domain. Compared to placebo or no treatment, vitamin D supplementation significantly improved bone mineral density (BMD) at the femoral neck (SMD 0.54; 95% CI 0.10 to 0.98; P = 0.02), reduced serum PTH level (SMD -0.49; 95% CI -0.76 to -0.22; P = 0.0003), decreased bone alkaline phosphatase (BAP) level (SMD -0.31; 95% CI -0.52 to -0.09; P = 0.006), increased serum calcium level (SMD 0.35; 95% CI 0.12 to 0.58; P = 0.003) and increased the risk of hypercalcemia (RR 1.92; 95% CI 1.23 to 3.01; P = 0.004). After treatment, there were no significant differences in the changes in lumbar spine BMD, 25-hydroxyvitamin D (25[OH]D) level, serum phosphate level, serum alkaline phosphatase (ALP) level, calciuria level, proteinuria level and estimated glomerular filtration rate (eGFR). No significant differences were observed in the incidence of fracture and acute graft rejection.
conclusionsVitamin D supplementation does not improve overall BMD or prevent fracture in KTRs. Vitamin D supplementation may effectively reduce serum PTH and BAP level. However, it may also increase the risk of hypercalcemia, necessitating the monitoring of serum calcium level.
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