Evidence map›Paper›PMID 40993761›Full record

ArticleArchives of public health = Archives belges de sante publique2025

Sustained frailty remission and future cardiovascular disease risk: a longitudinal study from the UK Biobank.

Mengting Liu, Qiang Zhang, Lianke Wang, Panpan Wang, Ying Qin, Qianyu Zhou, Mingyang Zhao, Tong Wanyan, Changqing Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of public health = Archives belges de sante publique, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mengting LiuSchool of Nursing and Health, Zhengzhou University, NO.101 Kexue Road, High-Tech Development Zone of States, Zhengzhou, 450001, Henan Province, P. R. China.
Qiang ZhangSchool of Nursing and Health, Zhengzhou University, NO.101 Kexue Road, High-Tech Development Zone of States, Zhengzhou, 450001, Henan Province, P. R. China.
Lianke WangSchool of Nursing and Health, Zhengzhou University, NO.101 Kexue Road, High-Tech Development Zone of States, Zhengzhou, 450001, Henan Province, P. R. China.
Panpan WangSchool of Nursing and Health, Zhengzhou University, NO.101 Kexue Road, High-Tech Development Zone of States, Zhengzhou, 450001, Henan Province, P. R. China.
Ying QinSchool of Nursing and Health, Zhengzhou University, NO.101 Kexue Road, High-Tech Development Zone of States, Zhengzhou, 450001, Henan Province, P. R. China.
Qianyu ZhouCollege of Public Health, Zhengzhou University, NO.100 Kexue Road, High-Tech Development Zone of States, Zhengzhou, 450001, Henan Province, P. R. China.
Mingyang ZhaoCollege of Public Health, Zhengzhou University, NO.100 Kexue Road, High-Tech Development Zone of States, Zhengzhou, 450001, Henan Province, P. R. China.
Tong WanyanCollege of Public Health, Zhengzhou University, NO.100 Kexue Road, High-Tech Development Zone of States, Zhengzhou, 450001, Henan Province, P. R. China.
Changqing SunSchool of Nursing and Health, Zhengzhou University, NO.101 Kexue Road, High-Tech Development Zone of States, Zhengzhou, 450001, Henan Province, P. R. China. zzugwsy@163.com.

Funding

the 2023 Zhongyuan Talent Program (Yucai Series): Zhongyuan Cultural Leading Talent Project 33220063the Henan Provincial Natural Science Foundation 242300420377the Science and Technology Research Project of Henan Province 242102310234
6 · The paper itself

Abstract

backgroundPhysical frailty has been recognized as reversible and an important risk factor for cardiovascular disease (CVD). However, little is known about sustained frailty remission and its impact on CVD. The study aimed to assess the association between sustained frailty remission and incident CVD.

methodsData were derived from the UK Biobank. Physical frailty was evaluated by the Fried frailty phenotype, and frailty transition patterns across three waves that is instance 0, instance 1, and instance 2 were defined. Incident CVD was defined by the International Classification of Diseases, 10th Revision (codes I00-I99). Cox proportional hazard models were used to calculate the hazard ratio (HR) and 95% confidence interval (95% CI), and stratified by age and sex.

resultsA total of 2,391 participants from the UK Biobank (mean age: 54.97 years) were included. 1,513 participants remained robust and 351 participants experienced sustained frailty remission. Over a median follow-up duration of 4.6 years, 508 participants developed CVD. Compared with stable pre-frail or frail individuals, those with sustained frailty remission had a lower future CVD risk (HR = 0.72, 95% CI: 0.53-0.99). The association remained significant in middle-aged adults (< 65 years; HR = 0.69, 95% CI: 0.50-0.98), and a stronger, though non-significant, association was observed in females (HR = 0.64, 95% CI: 0.38-1.08) than in males (HR = 0.80, 95% CI: 0.53-1.21).

conclusionsSustained frailty remission was associated with a reduced risk of developing CVD. Physical frailty may serve as an early indicator of CVD risk and a potential target for intervention strategies.

Indexed as

Cardiovascular diseaseDynamic natureFrailty remissionLongitudinal studyUK Biobank

Identifiers

PMID40993761
PMCPMC12462044

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.