Observational studyThe Medical journal of Australia2025
Changes in patient management after preoperative MRI for newly diagnosed breast cancer: a multicentre prospective observational study.
Observational study in The Medical journal of Australia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Survey of the Senologic International Society (SIS) on the Use of Preoperative Breast MRI in Early-Stage Breast Cancer: A Global Perspective on Current Practice.European journal of breast health · 2026Article
- Preoperative Breast MRI in Surgical Decision-Making for Breast Cancer: Clinical Value Beyond Sensitivity.Cancers · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
objectivesTo understand whether and how breast magnetic resonance imaging (MRI) at cancer diagnosis influences treatment planning, and whether subpopulations of patients with newly diagnosed breast cancer benefit in terms of most appropriate management.
designMulticentre prospective observational study.
settingSeven centres across New South Wales, Victoria and Western Australia during the period 15 September 2020 to 14 July 2022.
participantsPatients with newly diagnosed early breast cancer meeting predefined criteria for whom multidisciplinary team normal practice deemed MRI would aid treatment planning.
interventionPreoperative contrast-enhanced MRI.
main outcome measuresReasons for requesting MRI; pre-MRI versus post-MRI changes in treatment plans; changes justified by pathology findings.
results387 eligible participants were enrolled. MRI was most frequently requested for dense breasts (252 [65%]), clinical and/or radiological size discrepancy (161 [42%]), multifocality (108 [28%]) and young age (105 [27%]). Change in treatment plan after MRI occurred for 198 participants (51% [95% CI, 46-56%]), including a change in breast surgery plan for 119 participants (31% [95% CI, 26-36%]). More mastectomies were planned after MRI (15% v 28%; absolute risk difference [RD], 13 percentage points [95% CI, 9-17]; P < 0.001), including unilateral mastectomy (14% v 24%; RD, 10 percentage points [95% CI, 6-14]; P < 0.001) and bilateral mastectomy (1% v 4%; RD, 3 percentage points [95% CI, 1-5]; P < 0.001). No increases in planned mastectomies occurred for women aged ≥ 70 years (RD, -3 percentage points [95% CI, -15 to 9]; or in those for whom neoadjuvant therapy was planned (RD, 2 percentage points [95% CI, -11 to 14]). Change in surgery was deemed justified by pathology findings in 75 of 88 women who experienced a change (85% [95% CI, 75-91%]).
conclusionsPreoperative MRI findings led to changes in surgical management for a third of selected women with early breast cancer, increasing the mastectomy rate. In most cases, the changes were deemed appropriate. MRI findings did not change planned mastectomy in those aged ≥ 70 years, indicating that these women may not experience changes in surgical plans after such testing.
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