ArticleParasites & vectors2025
Comprehensive developmental somatic proteome atlas of Haemonchus contortus underpinned by a chromosome-scale genome and deep tandem mass spectrometry.
Article in Parasites & vectors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Genome-wide reconstruction of the intrinsic apoptosis pathway in Haemonchus contortus.BMC genomics · 2026Article
- Chemical perturbation reveals a cytoskeletal-trafficking vulnerability inFrontiers in pharmacology · 2026Article
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Authors and funding
5 authors.
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Abstract
backgroundHaemonchus contortus is a highly pathogenic, blood-feeding nematode that causes widespread disease and significant economic loss in livestock worldwide. Previous proteomic studies were constrained by incomplete genomic resources and limited analytical sensitivity, impeding comprehensive profiling across life stages.
methodsIn this study, we integrated advanced tandem mass spectrometry with a chromosome-scale genome assembly of the Haecon-5 strain to construct the most detailed somatic proteome of H. contortus to date.
resultsWe identified and quantified 7002 proteins across five key developmental stages/sexes-i.e. eggs, third-stage larvae (L3s), fourth-stage larvae (L4s), and adult female (Af) and adult male (Am) worms-tripling the number identified in an earlier study. Comparative analyses revealed pronounced stage-specific expression and functional specialisation, with parasitic stages enriched in proteins linked to metabolism, cellular function and environmental sensing. Fifteen proteins associated with the hypoxia-inducible factor 1 (HIF-1) signalling pathway were upregulated in parasitic stages, suggesting a role in adaptation to hypoxia. Additionally, 150 proteases implicated in haemoglobin degradation were characterised, and functional assays confirmed markedly elevated haemoglobinolytic activity in blood-feeding stages.
conclusionsThese findings offer key insights into H. contortus development and parasitism, and establish a high-resolution proteomic framework to underpin fundamental biological studies and to enable the discovery of molecular targets for novel interventions against this and related nematodes.
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