Evidence map›Paper›PMID 40993683›Full record

ArticleMalaria journal2025

Comparison of ARIMA and FB-Prophet time series models for the prediction of national and regional malaria incidence in Uganda.

Benjamin Fuller, Richard Ssekitoleko, Caroline Kyozira, Josh M Colston, Issa Makumbi, Andrew Bakainaga, Christopher C Moore, Herbert Isabirye Kiirya

Abstract readComparative Study
In one paragraph

Article in Malaria journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Benjamin FullerDivision of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, USA. qth5jr@uvahealth.org.
Richard SsekitolekoWorld Health Organization-Uganda, Kampala, Uganda.
Caroline KyoziraSurveillance and Public Health Department, Ministry of Health, Kampala, Uganda.
Josh M ColstonDivision of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, USA.
Issa MakumbiUganda Ministry of Health National Emergency Operations Center, Kampala, Uganda.
Andrew BakainagaWorld Health Organization-Uganda, Kampala, Uganda.
Christopher C Moore *Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, USA.
Herbert Isabirye Kiirya *Uganda Ministry of Health National Emergency Operations Center, Kampala, Uganda.

Funding

INFECTIOUS DISEASES TRAINING PROGRAMT32AI007046 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Alison K Criss, William A Petri · 1985 to 2026
$15.3M
The Planetary Child Health Observatory: an interdisciplinary research initiative and web-based dashboard for mapping enteric infectious diseases and their risk factors and interventions in LMICsK01AI168493 · NIAID · UNIVERSITY OF VIRGINIA · PI Josh M Colston · 2023 to 2026
$519k
Infectious Disease Training Grant, NIH T32AI007046NIAID NIH HHS K01 AI168493NIAID NIH HHS T32 AI007046World Health Organization 001
6 · The paper itself

Abstract

backgroundWithin sub-Saharan Africa, Uganda carries the third largest burden of malaria with 5% of global cases. Due to the stochastic nature of malaria incidence, resource allocation of preventive measures, rapid diagnostic tests, and chemotherapeutics is a significant challenge. To better identify areas at risk and address the challenge of resource allocation, this study aimed to: (1) characterize national and regional malaria incidence in Uganda, and (2) compare the performance of time series models in predicting malaria incidence at national and regional levels.

methodsAggregated data from District Health Information Software 2 (DHIS2), was used to assess national and regional malaria incidence in Uganda from 2020 through 2023. Auto-regressive moving average (ARIMA) models of national and regional malaria incidence were then created. The same data was applied to FB-Prophet, an open source generalized additive time series model. Training and validation datasets were created for each model, which ran for 41 and 6 months, respectively. Model performance was then evaluated via key performance indicators including mean average error (MAE), root mean square error (RMSE), and mean average percentage error (MAPE).

resultsThe incidence of malaria within Uganda increased from 200.5 cases per 1000 persons annually in 2021 to 265.4 cases per 1000 persons annually in 2022. The northern regions of West Nile and Acholi, along with Busoga region in the east, experienced the highest burden and incidence of malaria. The mean regional MAE, MAPE, and RMSE was 0.007, 31.2, and 0.01, respectively for ARIMA, and 0.01, 47.8, and 0.01, respectively for FB-Prophet. The ARIMA model outperformed the FB-Prophet model at the national level and in 14 of 15 regions.

conclusionsTime series models accurately predicted malaria incidence on a national and regional scale in Uganda. Both the ARIMA and FB-Prophet models have the potential to guide malaria resource allocation and response efforts among other malaria control interventions deployed in Uganda and possibly in other malaria endemic settings.

Indexed as

MalariaModels, StatisticalForecastingHumansIncidenceUganda

Identifiers

PMID40993683
PMCPMC12462331

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.