Evidence map›Paper›PMID 40993668›Full record

Trial reportBMC oral health2025

Comparative effects of hydrogen peroxide (Nanosil) and chlorhexidine mouthwashes on healing and pain after impacted mandibular third molar surgery: a randomized clinical trial.

Hamidreza Mahaseni Aghdam, Saeid Kasirolvalad, Esshagh Lasemi, Mona Farahmand, Rojin Ardalani, Mohsen Shalalvand

Abstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hamidreza Mahaseni AghdamDepartment of Oral and Maxillofacial Surgery and Implant Research Center, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, 19395/1495, Iran.
Saeid KasirolvaladSchool of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Esshagh LasemiDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Mona FarahmandDepartment of Orthodontics, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Rojin ArdalaniDepartment of Oral and Maxillofacial Radiology, School of Dentistry, Islamic Azad University, Khorasgan Branch, Isfahan, Iran.
Mohsen ShalalvandDepartment of Oral and Maxillofacial Radiology, School of Dentistry, Babol University of Medical Sciences, Babol, 19395/1495, Iran. mohsenshalalvand95@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study compares the effects of Nanosil METHODOLOGY: This double-blind, randomized clinical trial involved 62 patients (aged 18-50 years) with Pell and Gregory A and B impacted third molars. Participants were allocated to two groups: 15 cc of Nanosil

resultsHealing on day 3 was significantly better in the Nanosil group (p = 0.001). No infections or discharge were observed. A dry socket occurred in one patient in the Nanosil group, but it was not statistically significant. Swelling was significantly lower in the Nanosil group on day 3 (p < 0.001). Pain levels were similar in both groups.

conclusionNanosil promoted better healing and reduced swelling compared to chlorhexidine on the third day post-surgery. No significant differences were found regarding pain, infection, discharge, or dry socket.

trial registrationThe study was registered in the Iranian Clinical Trials Center with the code IRCT20171216037893N6 on 16/12/2021. https://irct.behdasht.gov.ir/trial/60568 .

Indexed as

Anti-Infective Agents, LocalChlorhexidineHydrogen PeroxideMolar, ThirdMouthwashesTooth ExtractionWound HealingAdolescentAdultDouble-Blind MethodDry SocketFemaleHumansMaleMandibleMiddle AgedAnti-Infective Agents, LocalChlorhexidineHydrogen PeroxideMouthwashesChlorhexidineHealingHydrogen peroxideImpacted third molarMouthwashPost-surgical complications

Identifiers

PMID40993668
PMCPMC12462199

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.