ArticleJournal of translational medicine2025
Quadrant asymmetry alteration of retinal degeneration in thyroid-associated ophthalmopathy.
Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Effects of endoscopic transnasal orbital decompression on anterior segment ocular blood flow and clinical outcome in thyroid-associated ophthalmopathy: a retrospective study.American journal of translational research · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
purposeTo measure alterations in quadrant asymmetry (QA) of retinal radial peripapillary capillary (RPC) density and to determine the association between subfield alterations and thyroid-associated ophthalmopathy (TAO).
methodsOptical coherence tomography angiography images of 51 control eyes and 80 TAO eyes were analyzed to quantify RPC density. QA was defined as the difference between the maximum and minimum RPC densities among four subfields. Comparisons of RPC QA between groups and the associations of QA with the occurrence of TAO were analyzed. Linear regression was conducted to determine the association of subfield alterations with visual field mean deviation (MD).
resultsQA of RPC density in TAO eyes was higher than in control eyes (9.58 ± 2.40 vs. 6.70 ± 2.01, P < 0.001), although no significant difference was observed in global RPC density between the TAO and control groups (P = 0.395). QA of RPC density demonstrated a high area under the curve (AUC = 0.816) for detecting TAO, whereas the AUC of global RPC density was only 0.564. Among the four subfields, only nasal RPC density showed a significant decrease in TAO eyes (48.03 ± 2.56 vs. 50.19 ± 2.79, P < 0.001). Univariate linear regression revealed that nasal RPC density was correlated with visual field MD (standardized coefficient = 0.243, P = 0.005), whereas RPC density in the other three subfields did not show significant correlations (all P ≥ 0.082).
conclusionAlterations in quadrant asymmetry of RPC density occurred in TAO, particularly decreased RPC density in the nasal subfield, which was significantly associated with visual field abnormalities in TAO.
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