Evidence map›Paper›PMID 40993638›Full record

ArticleBMC public health2025

Beyond additive effects: examining the combined impact of air pollutant interactions on pulmonary tuberculosis in China.

Zhe Pang, Xineng Jiang, Kui Liu, Yaling Feng, Jing Wei, Bin Chen, Bo Xie

Abstract read
In one paragraph

Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhe PangSchool of Urban Design, Wuhan University, Wuhan, 430072, China.
Xineng JiangLanxi County Center for Disease Control and Prevention, Zhejiang, 321100, Jinhua, China.
Kui LiuZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, 310051, China.
Yaling FengLanxi County Center for Disease Control and Prevention, Zhejiang, 321100, Jinhua, China.
Jing WeiMEEKL-AERM, College of Environmental Sciences and Engineering, Institute of Tibetan Plateau, and Center for Environment and Health, Peking University, 100871, Beijing, China.
Bin Chen *Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, 310051, China. bchen@cdc.zj.cn.
Bo Xie *School of Urban Design, Wuhan University, Wuhan, 430072, China. xiebo317@whu.edu.cn.

Funding

National Natural Science Foundation of China 42371252"Pioneer" and "Leading Goose" R&D Program of Zhejiang 2025C01134
6 · The paper itself

Abstract

backgroundVarious ambient air pollutants within a mixture may interact with each other and amplify or reduce the cumulative effects of individual air pollutants on health outcomes. However, health-related studies on the interactive effects of air pollutant mixtures remain limited. Additionally, the influence of greenness on health outcomes in the context of air pollutant mixtures has seldom been explored.

objectiveTo develop a joint analysis framework that focuses on the interactive effects among pollutants to evaluate the combined effects of ambient air pollutant mixtures on pulmonary tuberculosis (PTB) risks, taking into account greenness as a moderating factor.

methodsIn this case-control study conducted in Lanxi, China, 1128 newly diagnosed PTB cases from 2019 to 2021 were matched with 2256 controls by sex and age. To evaluate exposure, the 24-month average values of particulate matter with aerodynamic diameters of ≤ 2.5 µm (PM

resultsAdditive effect models showed that a one quartile increase in exposure to the air pollutant mixture was associated with elevated PTB risks (mixture odds ratio: 1.17, 95% confidence intervals: 1.07, 1.36), with NO

conclusionsTo reduce biases in air pollution control policies and maximize their health benefits, it is essential to assess both the additive and interactive effects when evaluating the health impacts of air pollutant mixtures. Furthermore, the influence of greenness should be considered in the context of these air pollutant mixtures.

Indexed as

Air PollutantsAir PollutionEnvironmental ExposureTuberculosis, PulmonaryAdultCase-Control StudiesChinaFemaleHumansMaleMiddle AgedParticulate MatterAir PollutantsParticulate MatterAdditive effectAir pollutant mixtureCase–control studyGreennessInteractive effectPulmonary tuberculosis

Identifiers

PMID40993638
PMCPMC12462355

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.