Trial reportBMC geriatrics2025
36-Week personalized resistance training improves muscle function and circulating myokines in older women with possible sarcopenic obesity: a randomized clinical trial.
Trial report in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative effectiveness of exercise modalities and nutritional supplementation for sarcopenic obesity in older adults: a network meta-analysis based on randomized controlled trials.Frontiers in public health · 2026Pooled it
- The effects of resistance training on myostatin in older adults with frailty and/or sarcopenia: a systematic review and meta analysis.BMC sports science, medicine & rehabilitation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundThis study aims to explore the effects of personalized resistance training on muscle function and serum myokines in possible sarcopenic obese older women.
methods25 possible SO older women were randomly divided into exercise group (n = 13) and control group (n = 12). According to the FITT-VP principle, personalized resistance training programs were developed based on their individual health differences. The training was implemented in three stages with gradually increasing intensity from low to moderate. Each session lasted 40 min, 3 times a week, for a total of 36 weeks. Body composition, muscle function, and serum myokines (irisin, IGF-1, and myostatin) were tested before and after the intervention in both groups.
resultsThe intervention yielded significant between-group improvements in body fat percentage (P < 0.05, Hedges' g = 1.42), ASMI (P < 0.01, Hedges' g = 1.79), HGS (P < 0.01, Hedges' g = 1.91), 6-metre walk speed (P < 0.01, Hedges' g = 1.36), five times sit-to-stand performance (P < 0.05, Hedges' g = 1.08), and TUG (P < 0.01, Hedges' g = 1.20). After 36 weeks, the exercise group also showed higher IGF-1 (P < 0.05, Hedges' g = 1.46) and lower MSTN (P < 0.01, Hedges' g = 1.02) levels compared to controls.
conclusionThe 36-week personalized resistance training program results in elevated serum IGF-1 concentrations and reduced myostatin levels, alongside independent improvements in muscle strength and muscle function among older women with probable sarcopenic obesity.
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