Evidence map›Paper›PMID 40993496›Full record

ArticleMikrochimica acta2025

A simple and rapid colorimetric sensor for uric acid detection based on ligand-modified silver nanoparticles with oxidase activity.

DongboYang, Guangda Xu, Jinkun Yan, Lefa Zhao

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

DongboYangCollege of Football, Shenyang Sport University, Shenyang, 110115, China.
Guangda XuSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Jinkun YanDepartment of Basic Teaching, Shenyang Sport University, Shenyang, 110102, China.
Lefa ZhaoDepartment of Basic Teaching, Shenyang Sport University, Shenyang, 110102, China. larry2012@syty.edu.cn.

Funding

Basic Scientific Research Project in Higher Education Institutions of the Department of Education of Liaoning Province LJ222510176003the Scientific Research Funding Project of the Department of Education of Liaoning Province WQN2019ST07
6 · The paper itself

Abstract

Novel silver nanoparticles modified with 1-methyl-1H-imidazole-2-carbaldehyde (AgNPs@MCA) with superior oxidase-like activity are reported for the first time. AgNPs@MCA directly utilized dissolved oxygen to catalyze the oxidation of the chromogenic substrate 3,3',5,5'-tetramethylbenzidine (TMB), generating blue oxidized TMB (oxTMB). Density functional theory (DFT) calculations were employed to elucidate the role of MCA in the catalytic process. Furthermore, leveraging the ability of uric acid (UA) to scavenge reactive oxygen species (ROS) in the system, a simple and rapid colorimetric method for UA detection was established. Under optimal conditions, the proposed method exhibited a linear range of 20-100 μM and a detection limit (LOD) of 1 μM. The assay demonstrated good selectivity, stability, and reproducibility. Detection results in actual human urine samples aligned with normal physiological levels, validating the potential of this colorimetric sensing approach for biomedical applications.

Indexed as

ColorimetryMetal NanoparticlesOxidoreductasesSilverUric AcidBenzidinesHumansLigandsLimit of DetectionOxidation-ReductionReproducibility of Results3,3',5,5'-tetramethylbenzidineBenzidinesLigandsOxidoreductasesSilverUric AcidAgNPs@MCAColorimetric sensorNanozymeOxidase-like activityUric acid detection

Identifiers

PMID40993496

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.