Evidence map›Paper›PMID 40993461›Full record

ArticleAnnals of surgical oncology2026

Survival Benefit of Adjuvant S-1 Chemotherapy in Patients Aged ≥ 80 Years with Gastric Cancer after Curative Resection: A Multicenter Cohort Study.

Shutaro Sumiyoshi, Takeshi Kubota, Hiroyuki Inoue, Kazuya Takabatake, Keiji Nishibeppu, Junichi Hamada, Toshiya Ochiai, Yosuke Ariyoshi, Atsushi Toma, Kenji Watanabe and 11 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Shutaro SumiyoshiDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Takeshi KubotaDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan. tkubot@koto.kpu-m.ac.jp.
Hiroyuki InoueDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Kazuya TakabatakeDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Keiji NishibeppuDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Junichi HamadaDepartment of Surgery, North Medical Center Kyoto Prefectural University of Medicine, Kyoto, Japan.
Toshiya OchiaiDepartment of Surgery, North Medical Center Kyoto Prefectural University of Medicine, Kyoto, Japan.
Yosuke AriyoshiDepartment of Surgery, Fukuchiyama City Hospital, Kyoto, Japan.
Atsushi TomaDepartment of Surgery, Fukuchiyama City Hospital, Kyoto, Japan.
Kenji WatanabeDepartment of Surgery, Kyoto Chubu Medical Center, Kyoto, Japan.
Nobuki YamaokaDepartment of Surgery, Kyoto Chubu Medical Center, Kyoto, Japan.
Soujin SaiDepartment of Surgery, Ayabe City Hospital, Kyoto, Japan.
Shozo IdeDepartment of Surgery, Maizuru Kyosai Hospital, Kyoto, Japan.
Tomoya HatakeyamaDepartment of Surgery, Maizuru Kyosai Hospital, Kyoto, Japan.
Yoshiki ItokawaDepartment of Surgery, National Hospital Organization Maizuru Medical Center, Kyoto, Japan.
Fumiaki OchiDepartment of Surgery, Japanese Red Cross Society Maizuru Hospital, Kyoto, Japan.
Hirotaka KonishiDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Hitoshi FujiwaraDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Miho SekimotoDepartment of General Medicine and Community Healthcare, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Satoru ShikataDepartment of General Medicine and Community Healthcare, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Atsushi ShiozakiDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe efficacy of adjuvant chemotherapy for gastric cancer (GC) in adult patients aged ≥ 80 years remains unclear because this population is often underrepresented in clinical trials. This study aimed to evaluate the impact of S-1 adjuvant chemotherapy on this age group following curative gastrectomy. PATIENTS AND

methodsThis retrospective multicenter study included 113 patients aged ≥ 80 years with pathological stage II/III GC who underwent curative D2 or D1+ gastrectomy between 2008 and 2020. Patients were classified according to whether they had received S-1 adjuvant chemotherapy. Overall survival (OS), recurrence-free survival (RFS), adverse events, and relative dose intensity (RDI) were analyzed.

resultsAmong the patients, 30 received S-1 and 83 underwent surgery alone. Baseline characteristics were generally balanced, although the S-1 group had a higher rate of D2 dissection and shorter postoperative hospital stays. The 5-year OS and RFS rates were significantly higher in the S-1 group (70.0% and 66.7%, respectively) than in the nonchemotherapy group (48.1% and 45.7%, respectively). Multivariable analysis confirmed S-1 administration as an independent prognostic factor for both OS and RFS. Grade ≥ 3 adverse events occurred in 22.3% of patients who received S-1. Patients who maintained an RDI ≥ 60% demonstrated improved RFS.

conclusionsAdjuvant chemotherapy with S-1 may improve survival in patients aged ≥ 80 years with stage II/III GC. Maintaining an adequate dose intensity appears to be critical for clinical benefits in this population.

Indexed as

Antimetabolites, AntineoplasticGastrectomyOxonic AcidStomach NeoplasmsTegafurAged, 80 and overChemotherapy, AdjuvantDrug CombinationsFemaleFollow-Up StudiesHumansMalePrognosisRetrospective StudiesSurvival RateAntimetabolites, AntineoplasticDrug CombinationsOxonic AcidS 1 (combination)TegafurAdjuvant chemotherapyGastric cancerOlder patientsPrognosisRelative dose intensityS-1

Identifiers

PMID40993461

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.