Evidence map›Paper›PMID 40993452›Full record

ArticleBulletin of experimental biology and medicine2025

Changes in the Structure of Cytochrome C Active Center under the Action of Phosphatidic Acid and Temperature.

I V Kirilina, G O Stepanov, Yu A Vladimirov, A N Osipov

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

I V KirilinaPirogov Russian National Research Medical University (Pirogov University), Ministry of Health of the Russian Federation, Moscow, Russia.
G O StepanovPirogov Russian National Research Medical University (Pirogov University), Ministry of Health of the Russian Federation, Moscow, Russia. stepanov_go@rsmu.ru.
Yu A VladimirovPirogov Russian National Research Medical University (Pirogov University), Ministry of Health of the Russian Federation, Moscow, Russia.
A N OsipovPirogov Russian National Research Medical University (Pirogov University), Ministry of Health of the Russian Federation, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The release of cytochrome C into the cytoplasm after formation of a complex with mitochondrial phospholipids underlays the mitochondrial pathway of apoptosis. Changes in the structure of cytochrome C complex active center depending on phosphatidic acid concentration and at different temperatures (25, 37, and 45°C) were studied. Changes in the active center structure were assessed by optical absorption at 695 nm and compared with the intensity of luminol-dependent chemiluminescence which is proportional to the peroxidase activity of cytochrome C-phosphatidic acid complex. It was found that increasing the temperature from 25 to 45°C leads to comparable changes in the conformation of cytochrome C active center and an increase in its peroxidase activity.

Indexed as

Cytochromes cPhosphatidic AcidsAnimalsCatalytic DomainMitochondriaPeroxidaseTemperatureCytochromes cPeroxidasePhosphatidic AcidsCytochrome CHyperthermiaMolecular mechanisms of apoptosisPhosphatidic acid

Identifiers

PMID40993452

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.