Evidence map›Paper›PMID 40993399›Full record

ArticleNature2025

Arousal as a universal embedding for spatiotemporal brain dynamics.

Ryan V Raut, Zachary P Rosenthal, Xiaodan Wang, Hanyang Miao, Zhanqi Zhang, Jin-Moo Lee, Marcus E Raichle, Adam Q Bauer, Steven L Brunton, Bingni W Brunton and 1 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Shallow recurrent decoders for neural and behavioural dynamics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Article
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  6. The Cost of Social Integration: Distinct Neural Inefficiency in Autistic Children Underlies Symptom Severity.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  7. Arousal state modulates human hippocampal ripples.bioRxiv : the preprint server for biology · 2026
    Article
  8. Cortical synchrony is reduced in Alzheimer's disease and relates to arousal state.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  9. Review
  10. Article
  11. Input-dependent directionality of interactions between cortical areas.bioRxiv : the preprint server for biology · 2026
    Article
  12. Article
  13. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Ryan V RautAllen Institute, Seattle, WA, USA. raut@wustl.edu.ORCID 0000-0002-8761-1431
Zachary P RosenthalDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-8787-0858
Xiaodan WangMallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Hanyang MiaoDepartment of Neurology, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0001-5757-859X
Zhanqi ZhangDepartment of Computer Science & Engineering, University of California San Diego, La Jolla, CA, USA.
Jin-Moo LeeDepartment of Neurology, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-3979-0906
Marcus E RaichleMallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-1847-9588
Adam Q BauerMallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Steven L BruntonDepartment of Mechanical Engineering, University of Washington, Seattle, WA, USA.ORCID 0000-0002-6565-5118
Bingni W BruntonDepartment of Biology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-4831-3466
J Nathan KutzDepartment of Applied Mathematics, University of Washington, Seattle, WA, USA.ORCID 0000-0002-6004-2275

Funding

Plasticizing the Cortex to Enhance Stroke RecoveryR37NS110699 · NINDS · WASHINGTON UNIVERSITY · PI LEE, JIN-MOO · 2019 to 2025
$3.5M
Targeting TFEB To Microglia and Monocytes to Enhance Amyloid DegradationR01NS094692 · NINDS · WASHINGTON UNIVERSITY · PI DIWAN, ABHINAV, LEE, JIN-MOO · 2017 to 2021
$2.4M
INFLUENCE OF INTERHEMISPHERIC CONNECTIVITY ON RECOVERY AFTER FOCAL ISCHEMIAR01NS084028 · NINDS · WASHINGTON UNIVERSITY · PI LEE, JIN-MOO · 2013 to 2017
$2.2M
OPTOGENETIC MAPPING OF CELL SPECIFIC CONNECTIONS IN THE MOUSE BRAIN AFTER STROKER01NS102870 · NINDS · WASHINGTON UNIVERSITY · PI BAUER, ADAM Q · 2018 to 2022
$2.1M
Determining the efficacy of therapeutic interventions after stroke from cell specific functional connectomesR01NS126326 · NINDS · WASHINGTON UNIVERSITY · PI ADAM Q BAUER · 2023 to 2026
$1.8M
NINDS NIH HHS R01 NS084028NINDS NIH HHS R01 NS094692NINDS NIH HHS R01 NS102870NINDS NIH HHS R01 NS126326NINDS NIH HHS R37 NS110699
6 · The paper itself

Abstract

Neural activity in awake organisms shows widespread, spatiotemporally diverse correlations with behavioural and physiological measurements

Indexed as

ArousalBrainModels, NeurologicalSpatio-Temporal AnalysisAnimalsCalciumFemaleMaleMiceMice, Inbred C57BLNeuronsNonlinear DynamicsOptical ImagingOxygenPupilTime FactorsCalciumOxygen

Identifiers

PMID40993399
PMCPMC12611781

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.