Evidence map›Paper›PMID 40993396›Full record

ArticleNature2025

Protecting double Holliday junctions ensures crossing over during meiosis.

Shangming Tang, Sara Hariri, Regina Bohn, John E McCarthy, Jennifer Koo, Mohammad Pourhosseinzadeh, Emerald Nguyen, Natalie Liu, Christopher Ma, Hanyu Lu and 2 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Structure and function of the synaptonemal complex.The Journal of cell biology · 2026
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Shangming TangHoward Hughes Medical Institute, University of California Davis, Davis, CA, USA.
Sara HaririHoward Hughes Medical Institute, University of California Davis, Davis, CA, USA.ORCID 0000-0003-4693-2359
Regina BohnHoward Hughes Medical Institute, University of California Davis, Davis, CA, USA.
John E McCarthyHoward Hughes Medical Institute, University of California Davis, Davis, CA, USA.
Jennifer KooHoward Hughes Medical Institute, University of California Davis, Davis, CA, USA.
Mohammad PourhosseinzadehHoward Hughes Medical Institute, University of California Davis, Davis, CA, USA.ORCID 0000-0001-9729-0056
Emerald NguyenHoward Hughes Medical Institute, University of California Davis, Davis, CA, USA.
Natalie LiuHoward Hughes Medical Institute, University of California Davis, Davis, CA, USA.
Christopher MaHoward Hughes Medical Institute, University of California Davis, Davis, CA, USA.
Hanyu LuHoward Hughes Medical Institute, University of California Davis, Davis, CA, USA.
Monica LeeHoward Hughes Medical Institute, University of California Davis, Davis, CA, USA.
Neil HunterHoward Hughes Medical Institute, University of California Davis, Davis, CA, USA. nhunter@ucdavis.edu.ORCID 0000-0003-1498-2327

Funding

UC Davis MCB T32 Administrative Supplement to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility (DEIA) MentorshipT32GM007377 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI CHEDIN, FREDERIC LOUIS · 1985 to 2023
$9.9M
Joint Molecule Resolution During Meiotic RecombinationR01GM074223 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI HUNTER, NEIL · 2005 to 2025
$6.0M
NIGMS NIH HHS R01 GM074223NIGMS NIH HHS T32 GM007377
6 · The paper itself

Abstract

Chromosomal linkages formed through crossover recombination are essential for the accurate segregation of homologous chromosomes during meiosis

Indexed as

Crossing Over, GeneticDNA, CruciformMeiosisAnimalsCell Cycle ProteinsChromosomal Proteins, Non-HistoneChromosome PairingCohesinsFemaleMaleMicePachytene StageSpermatocytesSynaptonemal ComplexCell Cycle ProteinsChromosomal Proteins, Non-HistoneCohesinsDNA, Cruciform

Identifiers

PMID40993396
PMCPMC12629981

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.