ArticleNature2025
Design of facilitated dissociation enables timing of cytokine signalling.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Accelerating protein design by scaling experimental characterization.Nature communications · 2026Article
- Automated synthetic cell-based screening for designed proteins with emergent functions.Nature communications · 2026Article
- Mapping and engineering the human cell-cell interactome.Nature biotechnology · 2026Review
- Modular Input-Output Biosensor Design UsingACS sensors · 2026Article
- Cordycepin Ameliorates Constant Light-Induced Thermogenic Dysfunction in Brown Adipose Tissue by Activating SIRT1-Mediated Mitochondrial Homeostasis.International journal of molecular sciences · 2026Article
- Reverse-engineering amyloid strains with generative protein design.bioRxiv : the preprint server for biology · 2026Article
- Generative Protein Design: From Deep Learning Algorithms to Translational Applications.International journal of molecular sciences · 2026Review
- Deep homology and design of proteasome chaperone proteins in Candidozyma auris.Nature communications · 2026Article
- Article
- Article
- Multivalency Enables Signal Processing at Single Protein Level.Journal of the American Chemical Society · 2025Article
Corrections and comments
- Update of
Authors and funding
22 authors.
Adam J BroermanInstitute for Protein Design, University of Washington, Seattle, WA, USA. broerman@uw.edu.ORCID 0000-0002-6878-1769
Christoph PollmannDepartment of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.
Yang ZhaoDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-6596-499X
Mauriz A LichtensteinInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0002-2124-8262
Mark D JacksonDepartment of Chemistry, University of Washington, Seattle, WA, USA.
Maxx H TessmerDepartment of Chemistry, University of Washington, Seattle, WA, USA.
Won Hee RyuDepartment of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA.
Masato OgishiDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-2421-7389
Mohamad H AbediInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Danny D SahtoeInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0001-9095-0744
Aza AllenInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Alex KangInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0001-5487-0499
Joshmyn De La CruzInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Evans BrackenbroughInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Banumathi SankaranMolecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID 0000-0002-3266-8131
Asim K BeraInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0001-9473-2912
Daniel M ZuckermanDepartment of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0001-7662-2031
Stefan StollDepartment of Chemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0003-4255-9550
K Christopher GarciaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-9273-0278
Florian PraetoriusInstitute for Protein Design, University of Washington, Seattle, WA, USA. florian.praetorius@ist.ac.at.ORCID 0000-0002-0806-8101
Jacob PiehlerDepartment of Biology/Chemistry, Osnabrück University, Osnabrück, Germany.ORCID 0000-0002-2143-2270
David BakerInstitute for Protein Design, University of Washington, Seattle, WA, USA. dabaker@uw.edu.ORCID 0000-0001-7896-6217
Funding
X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Vivian Stojanoff · 2019 to 2026
$38.6MUser Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2MUser Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Gregory L Hura · 2017 to 2026
$28.6MStructure-based engineering of immune cytokine signalingR01AI051321 · NIAID · STANFORD UNIVERSITY · PI Kenan Christopher GARCIA · 2002 to 2026
$5.6MStructure, function and engineering of immune cytokine receptor signalingR37AI051321 · NIAID · STANFORD UNIVERSITY · PI GARCIA, KENAN CHRISTOPHER · 2013 to 2022
$4.2MWESTPA: A high-performance framework for simulating at the frontiers of biologyR01GM115805 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LILLIAN T CHONG · 2015 to 2026
$4.0MDe Novo Design of Minibinder Antagonists for COVID-19 and Future PandemicsR01AI160052 · NIAID · UNIVERSITY OF WASHINGTON · PI BAKER, DAVID, FULLER, DEBORAH H. · 2021 to 2025
$3.5MEquipment Supplement: DEER spectroscopy tools for probing protein conformational dynamicsR35GM151956 · NIGMS · UNIVERSITY OF WASHINGTON · PI Stefan Stoll · 2024 to 2026
$1.4MHigh-sensitivity upgrade of DEER/EPR spectrometerS10OD021557 · OD · UNIVERSITY OF WASHINGTON · PI STOLL, STEFAN · 2017 to 2017
$495kGenetic and immunological dissection of coinhibitory crosstalks between human T cells and cancer cellsK00CA274708 · NCI · STANFORD UNIVERSITY · PI Masato Ogishi · 2024 to 2026
$297kNCI NIH HHS K00 CA274708NIAID NIH HHS R01 AI051321NIAID NIH HHS R01 AI160052NIAID NIH HHS R37 AI051321NIGMS NIH HHS P30 GM124165NIGMS NIH HHS P30 GM124169NIGMS NIH HHS P30 GM133893NIGMS NIH HHS R01 GM115805NIGMS NIH HHS R35 GM151956NIH HHS S10 OD021557
Abstract
Protein design has focused on the design of ground states, ensuring that they are sufficiently low energy to be highly populated
Indexed as
CytokinesInterleukin-2Protein EngineeringSignal TransductionAllosteric RegulationBiosensing TechniquesCrystallography, X-RayHumansKineticsModels, MolecularProtein BindingTime FactorsCytokinesInterleukin-2
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What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.