ArticleNature2025
Reprogramming neuroblastoma by diet-enhanced polyamine depletion.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Nicotinamide nucleotide transhydrogenase directly couples redox homeostasis to proline biosynthesis in human glioma.Molecular cell · 2026Article
- MYCN-driven metabolic remodelling of the tumour microenvironment in neuroblastoma: implications for stromal biology and CAF heterogeneity.Cancer metastasis reviews · 2026Review
- SUMOylation activates ECHS1 for adaptive catabolism in lung cancer.Cell death & disease · 2026Article
- Article
- Deciphering the MYCN-driven metabolic microenvironment of neuroblastoma.Trends in molecular medicine · 2026Review
- A dietary pan-amino acid dropout screenbioRxiv : the preprint server for biology · 2025Article
- Review
- High-dose DFMO alters protein translation in neuroblastoma.Neoplasia (New York, N.Y.) · 2025Article
- Polyamine Inhibition with DFMO: Shifting the Paradigm in Neuroblastoma Therapy.Journal of clinical medicine · 2025Review
- Molecular regulation and therapeutic targeting ofFrontiers in cell and developmental biology · 2025Review
Corrections and comments
- Update of
Authors and funding
22 authors.
Sarah CherkaouiPediatric Cancer Metabolism Laboratory, Children's Research Center, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-0636-4177
Christina S TurnDivision of Oncology and Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0003-3962-6740
Yuan YuanPediatric Cancer Metabolism Laboratory, Children's Research Center, University of Zurich, Zurich, Switzerland.
Wenyun LuDepartment of Chemistry, Princeton University, Princeton, NJ, USA.ORCID 0000-0003-1787-2617
Lifeng YangDepartment of Chemistry, Princeton University, Princeton, NJ, USA.
Matthew J McBrideDepartment of Chemistry, Princeton University, Princeton, NJ, USA.
Caroline EigenmannPediatric Cancer Metabolism Laboratory, Children's Research Center, University of Zurich, Zurich, Switzerland.
George E AllenBioinformatics Support Platform, Faculty of Medicine, Geneva, Switzerland.
Olesya O PanasenkoBioinformatics Support Platform, Faculty of Medicine, Geneva, Switzerland.
Lu ZhangLudwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ, USA.
Annette VuDivision of Oncology and Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Kangning LiuDivision of Oncology and Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Yimei LiDivision of Oncology and Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Om H GandhiDivision of Oncology and Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Lea F SurreyPerelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-6944-2232
Sandra D KienastPediatric Cancer Metabolism Laboratory, Children's Research Center, University of Zurich, Zurich, Switzerland.
Sebastian A LeidelDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland.
Michael WiererProteomics Research Infrastructure, Panum Institute, University of Copenhagen, Copenhagen, Denmark.
Eileen WhiteLudwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ, USA.ORCID 0000-0003-2961-3065
Joshua D RabinowitzDepartment of Chemistry, Princeton University, Princeton, NJ, USA. joshr@princeton.edu.ORCID 0000-0002-1247-4727
Michael D HogartyDivision of Oncology and Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. hogartym@chop.edu.ORCID 0000-0002-9221-4852
Raphael J MorscherPediatric Cancer Metabolism Laboratory, Children's Research Center, University of Zurich, Zurich, Switzerland. raphael.morscher@kispi.uzh.ch.ORCID 0000-0003-3378-9266
Funding
VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI DOUGLAS J EPSTEIN · 1986 to 2026
$48.3MTumor cell metabolism in actionR01CA163591 · NCI · RUTGERS, THE STATE UNIV OF N.J. · PI JOSHUA D RABINOWITZ, Eileen P. White · 2012 to 2026
$7.0MMetabolism in Action: Quantitative Fluxes in MammalsDP1DK113643 · NIDDK · PRINCETON UNIVERSITY · PI RABINOWITZ, JOSHUA D · 2016 to 2020
$5.7MRevealing cancer metabolism via mass spectrometry and isotope tracersR50CA211437 · NCI · PRINCETON UNIVERSITY · PI Wenyun Lu · 2016 to 2026
$1.3MIndirect calorimetry cages equipped for glucose and blood pressure telemetryS10OD025098 · OD · UNIVERSITY OF PENNSYLVANIA · PI BAUR, JOSEPH A. · 2019 to 2019
$750kNCI NIH HHS R01 CA163591NCI NIH HHS R50 CA211437NIDDK NIH HHS DP1 DK113643NIDDK NIH HHS P30 DK019525NIH HHS S10 OD025098
Abstract
Neuroblastoma is a highly lethal childhood tumour derived from differentiation-arrested neural crest cells
Indexed as
Cellular ReprogrammingDietNeuroblastomaPolyaminesAdenosineAmino AcidsAnimalsArginineCell DifferentiationCodonDisease Models, AnimalEflornithineFemaleHumansMaleMiceAdenosineAmino AcidsArginineCodonEflornithineOrnithinePolyamines
Identifiers
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.