ArticleNature2025
SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
–field-weighted citation impact
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Who cites it
26 citing papers in PubMed.
- Heterogeneous SPP1-expressing esophageal cancer cells license immunotherapy resistance by organizing an immunosuppressive niche.Neoplasia (New York, N.Y.) · 2026Article
- Article
- Chiral FeBioactive materials · 2026Article
- Macrophage regulation of extracellular matrix remodeling in aging skeletal muscle.Ageing research reviews · 2026Review
- Pancreatic Cancer-Advances in the Last 50 Years.World journal of surgery · 2026Review
- Targeting SPP1 requires moving beyond ligand blockade.Cellular & molecular immunology · 2026Article
- FerroScore: a statistical approach for quantifying tumor-related ferroptosis based on omics data.Briefings in bioinformatics · 2026Article
- Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy.MedComm · 2026Review
- C3Journal of translational medicine · 2026Article
- Exosome-mediated miR-4660 delivery inhibits OPN promoted hepatoma cells aggression through targeting LGALS3BP.Journal of cell communication and signaling · 2026Article
- Decoding the role of H19 in cholestatic liver injury using snRNA-seq, spatial transcriptomics, and machine learning-based disease prediction.Cell & bioscience · 2026Article
- Osteogenic-like Phenotypic Reprogramming Is Associated with Reduced Malignant Behaviors in Pancreatic Cancer Cells Involving MAPK-ERK Signaling.International journal of molecular sciences · 2026Article
- SPP1 knockdown inhibits invasion, migration and paclitaxel-induced Epithelial-Mesenchymal Transition in Cervical Cancer Cells through the TGF-β/Akt/Snail pathway.Scientific reports · 2026Article
- Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- SPP1 expression serves as a potential peripheral circulating biomarker for lung cancer prognostics and drives tumorigenesis.Genes & diseases · 2026Article
- Single-cell RNA sequencing reveals HMGA2 involvement in neoplastic aggressiveness and endothelial cell senescence in chondrosarcoma.Cell biology and toxicology · 2026Article
- Decoding muscle-resident Schwann cell dynamics during neuromuscular junction remodeling.JCI insight · 2026Article
- Distinct and cooperative roles of host and tumor Osteopontin in colorectal cancer liver metastasis.bioRxiv : the preprint server for biology · 2026Article
- Decoding the Role of H19 in Cholestatic Liver Injury Using snRNA-seq, Spatial Transcriptomics, and Machine Learning-Based Disease Prediction.Research square · 2026Article
- Spatial transcriptomic analysis of kidney biopsies identifies activation of complement and SPP1 networks inFrontiers in nephrology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Huafu Li *The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
Linxiang Lan *The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.ORCID 0000-0002-8409-4336
Hengxing Chen *The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
May Zaw ThinThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.ORCID 0000-0003-0036-2776
Hari PsSystems and Precision Cancer Medicine Laboratory, Division of Molecular Pathology, The Institute of Cancer Research, Sutton, UK.
Jessica K NelsonThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
Ian M EvansThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.ORCID 0000-0002-0468-8274
E Josue RuizThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
Rongjie ChengThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
Li TranThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.ORCID 0000-0002-1956-6544
Mark AllenBiological Services Unit, The Institute of Cancer Research, London, UK.ORCID 0009-0001-1570-8218
Jian MaThe Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Tingzhuang YiThe Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Chunming WangThe Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Yulong HeThe Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.ORCID 0000-0002-1902-0963
Naomi GuppyNina Barough Pathology Core Facility, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.ORCID 0000-0003-1004-3605
Anguraj SadanandamSystems and Precision Cancer Medicine Laboratory, Division of Molecular Pathology, The Institute of Cancer Research, Sutton, UK.ORCID 0000-0001-8485-5150
Shao-Zhen LinMechanobiology Institute, National University of Singapore, Singapore, Singapore.
Changhua ZhangThe Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China. zhchangh@mail.sysu.edu.cn.ORCID 0000-0003-4358-4096
Axel BehrensThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK. Axel.Behrens@icr.ac.uk.ORCID 0000-0002-1557-1143
Funding
Breast Cancer Now Toby Robins Research CentreNational Natural Science Foundation of ChinaScience and Technology planning project of Guangdong province
Abstract
Elucidating the complex network of communication between tumour cells is central to understanding cell fate decisions and progression of pancreatic ductal adenocarcinoma (PDAC)
Indexed as
Carcinoma, Pancreatic DuctalCell LineageMesenchymal Stem CellsOsteopontinPancreatic NeoplasmsAnimalsBone Morphogenetic Protein 2CarcinogenesisCell DifferentiationCell Line, TumorCytokinesEpithelial CellsEpithelial-Mesenchymal TransitionFemaleHumansIntercellular Signaling Peptides and ProteinsBMP2 protein, humanBone Morphogenetic Protein 2CytokinesGREM1 protein, humanGrem1 protein, mouseIntercellular Signaling Peptides and ProteinsOsteopontinSPP1 protein, humanSpp1 protein, mouse
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.