Evidence map›Paper›PMID 40993389›Full record

ArticleNature2025

Collective homeostasis of condensation-prone proteins via their mRNAs.

Rupert Faraway, Neve Costello Heaven, Holly Digby, Klara Kuret Hodnik, Jure Rebselj, Oscar G Wilkins, Anob M Chakrabarti, Ira A Iosub, Neža Vadnjal, Rhys Dore and 4 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rupert Faraway *The Francis Crick Institute, London, UK. rupert.faraway@gmail.com.ORCID 0000-0002-1217-795X
Neve Costello Heaven *The Francis Crick Institute, London, UK.
Holly DigbyThe Francis Crick Institute, London, UK.ORCID 0000-0003-1360-9686
Klara Kuret HodnikNational Institute of Chemistry, Ljubljana, Slovenia.ORCID 0000-0002-8445-8080
Jure RebseljNational Institute of Chemistry, Ljubljana, Slovenia.ORCID 0009-0002-3737-026X
Oscar G WilkinsThe Francis Crick Institute, London, UK.
Anob M ChakrabartiThe Francis Crick Institute, London, UK.ORCID 0000-0002-6841-5718
Ira A IosubThe Francis Crick Institute, London, UK.ORCID 0000-0002-2924-2471
Neža VadnjalNational Institute of Chemistry, Ljubljana, Slovenia.ORCID 0000-0003-4790-0068
Rhys DoreUK Dementia Research Institute at King's College London, London, UK.ORCID 0000-0001-8417-8743
Lea KnezThe Francis Crick Institute, London, UK.
Stefan L AmeresMax Perutz Labs, University of Vienna, Vienna BioCenter, Vienna, Austria.ORCID 0000-0002-8248-3098
Clemens PlaschkaResearch Institute of Molecular Pathology, Vienna BioCenter, Vienna, Austria.ORCID 0000-0002-6020-9514
Jernej UleThe Francis Crick Institute, London, UK. jernej.ule@kcl.ac.uk.ORCID 0000-0002-2452-4277

Funding

European Research Council 835300Wellcome Trust 215593Wellcome Trust 227465Wellcome Trust CC0102
6 · The paper itself

Abstract

The concentration of proteins containing intrinsically disordered regions must be tightly controlled to maintain cellular homeostasis

Indexed as

Biomolecular CondensatesHomeostasisRNA-Binding ProteinsRNA, MessengerAnimalsArginineHumansPhosphorylationPurinesArgininepurinePurinesRNA-Binding ProteinsRNA, Messenger

Identifiers

PMID40993389
PMCPMC12629991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.