ArticleNature2025
Ribonucleotide incorporation into mitochondrial DNA drives inflammation.
Erratum issuedAbstract read
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Mechanistic reprogramming of the mtDNA-cGAS-STING axis in cellular senescence: from mitochondrial homeostatic disruption to inflammatory and immune outcomes.Biogerontology · 2026Review
- Cooperation between Adh and OR5M11 contributes to the lung pathogenicity of Actinobacillus pleuropneumoniae by facilitating the NLRP3-mediated inflammatory response.Veterinary research · 2026Article
- Article
- Ribonucleotides Amplify Mitochondrial DNA-Driven cGAS-STING Activation via FdUMP-ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mitochondrial homeodynamics in ageing: mechanisms, resilience, and interventions.Biogerontology · 2026Review
- Cardiomyocyte-intrinsic somatic mtDNA mutations induce an OXPHOS-dependent immune response and promote progressive heart failure.Science advances · 2026Article
- Article
- Nucleotide Metabolism in Health and Disease.MedComm · 2026Review
- Pol γ possesses separate metal binding sites for polymerase and strand displacement functions.Nucleic acids research · 2026Article
- Hypoxia-preconditioned mitochondrial transplantation multidirectionally modulates Schwann cell functions to repair peripheral nerve injury in rats.Journal of orthopaedic translation · 2026Article
- Mitochondrial quality control in human ageing and longevity.Nature metabolism · 2026Review
- Article
- Mitochondria as convergence hubs for innate immunity pathways.Communications biology · 2026Review
- Mitochondrial DNA release and inflammation in mitochondrial disease pathogenesis.Brain : a journal of neurology · 2026Review
- Pathogenic variants in the autophagy-tethering factor EPG5 drive neurodegeneration through mitochondrial dysfunction and innate immune activation.Nature communications · 2026Article
- Article
- Single-cell multi-omic analysis of mitochondrial mutational mosaicism and dynamics.Nature communications · 2026Article
- Cardiomyocyte-Derived USP20 Attenuates Diabetic Cardiomyopathy by Facilitating the Degradation of STING and Mitigating STING-Mediated Inflammation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- The importance of mitochondria and mitochondrial calcium signaling in health and disease: an updated outlook on inflammation.Journal of translational medicine · 2026Review
- Nucleotide salvage, genome instability, and potential therapeutic applications.Nucleic acids research · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
22 authors.
Amir Bahat *Max Planck Institute for Biology of Ageing, Cologne, Germany.
Dusanka Milenkovic *Max Planck Institute for Biology of Ageing, Cologne, Germany.
Eileen CorsMax Planck Institute for Biology of Ageing, Cologne, Germany.
Mabel BarnettMax Planck Institute for Biology of Ageing, Cologne, Germany.
Sadig NiftullayevMax Planck Institute for Biology of Ageing, Cologne, Germany.
Athanasios KatsalifisMax Planck Institute for Biology of Ageing, Cologne, Germany.ORCID 0000-0003-3494-7617
Marc SchwillMax Planck Institute for Biology of Ageing, Cologne, Germany.ORCID 0009-0006-6264-5375
Petra KirschnerMax Planck Institute for Biology of Ageing, Cologne, Germany.
Thomas MacVicarMax Planck Institute for Biology of Ageing, Cologne, Germany.
Patrick GiavaliscoMax Planck Institute for Biology of Ageing, Cologne, Germany.ORCID 0000-0002-4636-1827
Louise JenningerInstitute for Biomedicine, University of Gothenburg, Gothenburg, Sweden.
Anders R ClausenInstitute for Biomedicine, University of Gothenburg, Gothenburg, Sweden.
Vincent PaupeMedical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Julien PrudentMedical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0003-3821-6088
Nils-Göran LarssonDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-5100-996X
Manuel RoggInstitute of Surgical Pathology, Faculty of Medicine, Medical Center-University of Freiburg, Freiburg, Germany.ORCID 0000-0002-6658-9159
Christoph SchellInstitute of Surgical Pathology, Faculty of Medicine, Medical Center-University of Freiburg, Freiburg, Germany.
Isabella MuylaertInstitute for Biomedicine, University of Gothenburg, Gothenburg, Sweden.
Erik LarssonInstitute for Biomedicine, University of Gothenburg, Gothenburg, Sweden.
Hendrik NolteMax Planck Institute for Biology of Ageing, Cologne, Germany.
Maria FalkenbergInstitute for Biomedicine, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0001-8713-173X
Thomas LangerMax Planck Institute for Biology of Ageing, Cologne, Germany. tlanger@age.mpg.de.ORCID 0000-0003-1250-1462
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic dysregulation can lead to inflammatory responses
Indexed as
DNA, MitochondrialInflammationRibonucleotidesAgingAnimalsCellular SenescenceCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseCytosolDeoxyribonucleotidesFemaleHumansMaleMembrane ProteinsMetalloendopeptidasesMiceMice, Inbred C57BLcGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDeoxyribonucleotidesDNA, MitochondrialMembrane ProteinsMetalloendopeptidasesMitochondrial ProteinsNucleotidyltransferasesRibonucleotidesSting1 protein, mouseSTING Protein
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.