ArticleNature2025
LRP8 is a receptor for tick-borne encephalitis virus.
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Structures of asymmetric particles of tick-borne encephalitis virus provide insight into flavivirus assembly and maturation.Science advances · 2026Article
- Protective human antibodies against Powassan virus.Journal of virology · 2026Article
- Nairobi sheep disease virus: an emerging threat with unresolved pathogenesis and zoonotic potential.Journal of virology · 2026Review
- Targeted extracellular degradation of LRP8 promotes ferroptosis in cancer cells.bioRxiv : the preprint server for biology · 2026Article
- From CRISPR functional genomics to synthetic interventions: engineering antiviral strategies.Journal of virology · 2026Review
- Design of a neutralizing and protective pan-encephalitic alphavirus receptor decoy protein.Science translational medicine · 2026Article
- Antiviral effect of chelerythrine chloride against tick-borne encephalitis virus.Virology journal · 2026Article
- Article
- LRP8-dependent neurotropism of tick-borne encephalitis virus: From species-specific entry gateway to zoonotic spillover and receptor-mimetic therapy.Innovation (Cambridge (Mass.)) · 2026Review
- Status and outlook of mRNA therapeutics for viral diseases.EMBO molecular medicine · 2026Review
- Low density lipoprotein receptor-related protein 8: a critical receptor for tick-borne encephalitis virus entry.Signal transduction and targeted therapy · 2025Article
- LRP8 is an entry receptor for tick-borne encephalitis viruses.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors.
Eva Mittler *Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA. eva-maria.mittler@einsteinmed.edu.ORCID 0000-0002-5935-6314
Alexandra L Tse *Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Pham-Tue-Hung Tran *Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-8366-9310
Catalina Florez *United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Javier JanerDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Renata VarnaiteDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden.
Ezgi KasikciDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Vasantha Kumar MvDepartment of Biochemistry, Albert Einstein College of Medicine, New York, NY, USA.
Michaela LoomisUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Wanda ChristDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-3886-5248
Erik CazaresUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.ORCID 0000-0002-4218-9775
Russell R BakkenUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Caroline K MartinDepartment of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.ORCID 0000-0001-9448-9182
Xiankun ZengUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.ORCID 0000-0003-3526-8755
Jo Lynne RaymondUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Mansoureh ShahsavaniDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-6923-8389
Sara KhanalUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Eric R WilkinsonUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Rischa Maya OktaviaInstitut Pasteur, Université Paris Cité, Structural Virology Unit, Paris, France.
Megan M SloughDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Denise HaslwanterDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.ORCID 0000-0003-2727-0468
Julianna HanDepartment of Microbiology, University of Chicago, Chicago, IL, USA.
Jacob BerriganDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Ebba RosendalLaboratory for Molecular Infection Medicine Sweden, Umeå University, Umeå, Sweden.ORCID 0000-0001-8512-0535
Margaret KielianDepartment of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.ORCID 0000-0002-7395-4791
Balaji ManicassamyDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.ORCID 0000-0003-1964-0967
Anna K ÖverbyLaboratory for Molecular Infection Medicine Sweden, Umeå University, Umeå, Sweden.ORCID 0000-0001-6553-0940
Anna FalkDepartment of Experimental Medical Science, Lund Stem Cell Center, Science for Life Laboratory, Lund University, Lund, Sweden.ORCID 0000-0003-1634-8610
Giovanna Barba-SpaethInstitut Pasteur, Université Paris Cité, Structural Virology Unit, Paris, France.ORCID 0000-0003-2069-9501
Felix A ReyInstitut Pasteur, Université Paris Cité, Structural Virology Unit, Paris, France.ORCID 0000-0002-9953-7988
Jonas KlingströmDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-9076-1441
Evripidis GavathiotisDepartment of Biochemistry, Albert Einstein College of Medicine, New York, NY, USA.ORCID 0000-0001-6319-8331
Andrew S HerbertUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA. andrew.s.herbert4.civ@health.mil.ORCID 0009-0001-5256-7733
Kartik ChandranDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA. kartik.chandran@einsteinmed.edu.ORCID 0000-0003-0232-7077
Sara Gredmark-RussDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden. sara.gredmark.russ@ki.se.ORCID 0000-0002-2446-4323
Funding
WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI Ulrich Steidl · 1985 to 2026
$111.2MDissecting the receptor-mediated infection mechanisms of hantavirusesR01AI132633 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CHANDRAN, KARTIK · 2017 to 2021
$3.2MRegulation of innate antiviral responses by the DNA-binding transcriptional repressor complex CIC-ATXN1/LR01AI165932 · NIAID · UNIVERSITY OF IOWA · PI Balaji Manicassamy · 2022 to 2026
$3.0MInvestigation of host glycan requirements for the transmission of influenza viruses at the human-animal interfaceR01AI174584 · NIAID · UNIVERSITY OF IOWA · PI Balaji Manicassamy · 2024 to 2026
$2.3MMechanisms of novel host factors in alphavirus infectionR21AI182834 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI MARTIN, CAROLINE K · 2024 to 2025
$462kNCI NIH HHS P30 CA013330NIAID NIH HHS R01 AI132633NIAID NIH HHS R01 AI165932NIAID NIH HHS R01 AI174584NIAID NIH HHS R21 AI182834
Abstract
Tick-borne encephalitis virus (TBEV) causes tick-borne encephalitis (TBE), a severe and sometimes life-threatening disease characterized by viral invasion of the central nervous system with symptoms of neuroinflammation
Indexed as
Encephalitis, Tick-BorneEncephalitis Viruses, Tick-BorneLDL-Receptor Related ProteinsReceptors, VirusAnimalsBrainCell LineCRISPR-Cas SystemsFemaleHEK293 CellsHumansMaleMiceNeuronsReelin ProteinViral Envelope ProteinsLDL-Receptor Related Proteinslow density lipoprotein receptor-related protein 8Receptors, VirusReelin ProteinRELN protein, humanReln protein, mouseViral Envelope Proteins
Identifiers
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LicenceCC BY-NC
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.