Evidence map›Paper›PMID 40993330›Full record

ArticleGenes and immunity2025

Dexmedetomidine relieves LPS-induced acute lung injury by boosting HIF-1a/ACOD1 driven anti-inflammatory macrophage polarization.

Ning Zhang, Tangbing Chen, Yintao Chang, Mingzhi Cao, Huan Wang, Chengli Wu, Hong Jiang

Abstract read
PubMed Publisher
In one paragraph

Article in Genes and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ning Zhang *Department of Thoracic Surgery, 905th Hospital of People's Liberation Army Navy, Naval Medical University, Shanghai, China.
Tangbing Chen *Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yintao Chang *Department of Thoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.
Mingzhi CaoDepartment of Thoracic Surgery, 905th Hospital of People's Liberation Army Navy, Naval Medical University, Shanghai, China.
Huan WangDepartment of Thoracic Surgery, 905th Hospital of People's Liberation Army Navy, Naval Medical University, Shanghai, China.
Chengli WuDepartment of Oncology, 905th Hospital of People's Liberation Army Navy, Naval Medical University, Shanghai, China. Wuchlshhai266@outlook.com.
Hong JiangDepartment of Thoracic Surgery, 905th Hospital of People's Liberation Army Navy, Naval Medical University, Shanghai, China. Hojiang_sh@163.com.ORCID 0009-0000-9337-9248

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute lung injury (ALI) is a common and life-threatening lung disease. This study investigated the mechanism by which dexmedetomidine (Dex) alleviates lipopolysaccharide (LPS)-induced ALI, focusing on its regulation of macrophage autophagy and polarization. Initially, a mouse model of LPS-induced ALI was pretreated with Dex. Pulmonary function, histopathological changes, apoptosis, macrophage numbers in bronchoalveolar lavage fluid (BALF), M1/M2 macrophage ratios, iNOS/Arg-1/LC3/P62 fluorescence intensity, and autophagy flux were assessed. Subsequently, RAW264.7 macrophages were treated with LPS and Dex, transfected with si-ACOD1 or si-HIF-1α, and co-cultured with mouse pulmonary microvessel endothelial cells (MPMVECs). The results showed that Dex relieved autophagy flux blockage and promoted autophagy in ALI mice. LPS promoted ACOD1 and HIF-1α levels, and Dex further enhanced their levels to boost macrophage autophagy and M2 polarization. ACOD1 was transcriptionally regulated by HIF-1α. Collectively, Dex mitigated LPS-induced MPMVEC injury and ALI by enhancing HIF-1α-mediated ACOD1 transcription, thus promoting macrophage autophagy and M2 polarization.

Indexed as

Acute Lung InjuryDexmedetomidineHypoxia-Inducible Factor 1, alpha SubunitMacrophagesAnimalsAutophagyLipopolysaccharidesMaleMiceMice, Inbred C57BLRAW 264.7 CellsDexmedetomidineHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitLipopolysaccharides

Identifiers

PMID40993330

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.