ArticleCommunications biology2025
Non-muscle myosin II-dependent cumulus cell migration at ovulation is required for sperm to reach the egg in mice.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Interfollicular communication among preovulatory follicles after luteinizing hormone signaling.Endocrinology · 2026Article
- Proprotein convertase activity regulates cumulus-oocyte-complex matrix integrity and cumulus cell migration during ovulation via a GDF9-dependent mechanism.bioRxiv : the preprint server for biology · 2026Article
- Article
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Authors and funding
2 authors.
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Abstract
At ovulation in mammals, epidermal growth factor (EGFR) signaling in the cumulus granulosa cells that enclose the egg causes them to generate an extracellular matrix and become dispersed within it. This process, termed expansion, is required for sperm to reach the egg. The extracellular signal-related kinase (ERK) pathway mediates matrix production, but the mechanism responsible for cell dispersion is poorly understood. We show that EGFR signaling activates non-muscle myosin II (NMII) in the cumulus cells and that NMII activity is required for full expansion. NMII activation does not require ERK signaling, but instead depends on the Rho-associated coiled-coil containing kinases (ROCK) and the myotonic dystrophy kinase-related CDC42-binding kinases (MRCK). Blocking ROCK or MRCK impairs the ability of the cumulus cells to migrate and reduces the number of sperm that penetrate through the cumulus layer to reach the oocyte. EGFR thus promotes cumulus layer expansion by integrating ERK-dependent production of the matrix with NMII-dependent migration of the cumulus cells within it.
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Registered trials
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