ArticleCommunications medicine2025
UK Biobank study of the association between circadian syndrome and cardio-kidney events or all-cause mortality.
Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
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Who cites it
6 citing papers in PubMed.
- Relative circadian disruption in urinary excretion associates with renal function in biopsy-proven primary glomerular diseases: a cross-sectional study using the novel CRDI metric.Renal failure · 2026Article
- Circadian syndrome and its components in relation to incident gastroesophageal reflux disease: a prospective cohort study from the UK Biobank.BMC public health · 2026Article
- Prospective association between circadian syndrome and incident chronic lung disease in the CHARLS and ELSA cohorts.Scientific reports · 2026Article
- Non-traditional metabolic indices predict incident circadian syndrome in middle-aged and older Chinese adults: a nationwide prospective cohort study and machine learning analysis.Lipids in health and disease · 2026Observational
- Association of Circadian Syndrome with Incident Risk of 23 Site-Specific Cancers: A Large-Scale Prospective Study in the UK Biobank.Research (Washington, D.C.) · 2026Article
- Glycaemic Status Modifies the Association Between Cardiometabolic Index and Cardio-Kidney Outcomes: A Multi-Cohort Analysis.Diabetes/metabolism research and reviews · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCircadian syndrome (CircS) has demonstrated a strong association with the occurrence of cardiovascular disease (CVD), as well as chronic kidney disease (CKD). However, the association of CircS with cardiac-kidney events (CKE) or even mortality is unknown. This study was to evaluate whether CircS was related with CKE or all-cause mortality.
methodsThis prospective study analyzed data from 295,378 participants in the UK Biobank (UKB) cohort. CircS was characterized by the components of metabolic syndrome (MetS), along with short sleep and depression. We applied Cox regression analyses to examine the associations between CircS and composite outcome of CKE or all-cause mortality.
resultsAmong the 295,378 included participants (median age, 58 years; 55.7% female), we find that 28,027 primary outcome events are recorded during a median follow-up of 13.6 years. Findings reveal that CircS (hazard ratio [HR] 1.379; 95% confidence interval [CI] 1.319-1.441) demonstrates a significant positive association with the primary outcome. With the increase in CircS score, the risk of the primary outcome also increases. Among the seven components, depression (HR 1.518; 95% CI 1.426-1.616) emerges as the strongest contributing factor. Furthermore, we also find that CircS is a significant risk factor for CKE (HR 1.143; 95% CI 1.044-1.251) and has a greater impact on CKE with CVD-first and CKE with renal failure.
conclusionsCircS is strongly linked to increased CKE and all-cause mortality risk, highlighting the need for greater clinical focus on this syndrome. This correlation also provides theoretical support for the cardiovascular-kidney-metabolic syndrome concept.
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