Evidence map›Paper›PMID 40993201›Full record

ArticleScientific reports2025

Fibre supplementation alters the gastrointestinal microbiome, the microbial metabolites and indicators of neurodegeneration in a mouse model of Alzheimer´s disease.

Linda F Böswald, Jasmin Wenderlein, Martin Bachmann, Annette Zeyner, Klaus Neuhaus, Frederike Schäfer, Axel Imhof, Shibojyoti Lahiri, Josephine Gruetzke, Bastian Popper

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Linda F Böswald *Core Facility Animal Models, Biomedical Center, Medical Faculty, Ludwig-Maximilians- Universität München, Großhaderner Str. 9, DE-82152, Planegg-Martinsried, Germany. Linda.boeswald@lmu.de.
Jasmin Wenderlein *German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany.
Martin BachmannGerman Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany.
Annette ZeynerInstitute of Agricultural and Nutritional Sciences, Martin Luther University Halle- Wittenberg, Theodor-Lieser-Str. 11, 06120, Halle (Saale), Germany.
Klaus NeuhausCore Facility Microbiome, ZIEL Institute for Food & Health, Technical University of Munich, Weihenstephaner Berg 3, Freising, Germany.
Frederike SchäferFaculty of Medicine, Biomedical Center, Protein Analysis Unit, Ludwig-Maximilians- Universität München, Großhaderner Str. 9, DE-82152, Planegg-Martinsried, Germany.
Axel ImhofFaculty of Medicine, Biomedical Center, Protein Analysis Unit, Ludwig-Maximilians- Universität München, Großhaderner Str. 9, DE-82152, Planegg-Martinsried, Germany.
Shibojyoti LahiriFaculty of Medicine, Biomedical Center, Protein Analysis Unit, Ludwig-Maximilians- Universität München, Großhaderner Str. 9, DE-82152, Planegg-Martinsried, Germany.
Josephine GruetzkeGerman Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany.
Bastian PopperCore Facility Animal Models, Biomedical Center, Medical Faculty, Ludwig-Maximilians- Universität München, Großhaderner Str. 9, DE-82152, Planegg-Martinsried, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer´s disease is a neurodegenerative disease with high global prevalence and no cure available. It is known that the microbiota-gut-brain-axis plays a role in the pathogenesis, but the pathways are not fully understood yet. To elucidate the role of dietary fibre supplementation on this axis in a 5xFAD mouse model of Alzheimer´s disease, a feeding trial with an inulin supplement was conducted. At the start (Basis, n = 11) and after 7 weeks with (AD + F; n = 15) and without (AD; n = 15) supplementation, the mice were sacrificed and the following samples were taken: ingesta for 16 S rRNA sequencing and short-chain fatty acid (SCFA) analysis, and brain tissue for amyloid-beta staining and proteome analysis. The microbiota patterns in stomach, small intestine, caecum and colon differed between AD and AD + F. SCFA concentrations were significantly higher in group AD + F as compared to AD and Basis. In the AD mice, plaque load was significantly increased as compared to Basis, while a reduction in AD + F as compared to AD was observed. The brain proteome also differed between AD + F and AD, indicating a beneficial effect of the inulin supplementation, possibly mediated in part by microbial acetate. Since prebiotic substances like inulin are also part of human diets, this should be investigated further in the translational context.

Indexed as

Alzheimer DiseaseDietary FiberDietary SupplementsGastrointestinal MicrobiomeAmyloid beta-PeptidesAnimalsBrainDisease Models, AnimalFatty Acids, VolatileInulinMaleMiceMice, TransgenicProteomeAmyloid beta-PeptidesDietary FiberFatty Acids, VolatileInulinProteome5xFAD mouseInulinMicrobiotaNeurologyPrebioticSCFA

Identifiers

PMID40993201
PMCPMC12460888

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.