ArticleScientific reports2025
The long-term neuroprotective effect of MIND and Mediterranean diet on patients with Alzheimer's disease.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- The effect of the Mediterranean diet combined with physical activity on cognitive function in older adults: a scoping review.Journal of the International Society of Sports Nutrition · 2026Article
- Biological signature of dietary patterns in older adults: findings from a population-based study.BMC medicine · 2026Article
- Review
- Exploring the associations between lifestyle and dietary patterns with preclinical alzheimer's disease: findings from La Rioja cohort study.European journal of nutrition · 2026Article
- Association between dietary patterns and CAIDE-predicted dementia risk: A 20-year cohort of the Korean Genome and Epidemiology study.GeroScience · 2026Article
- Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation-Energy Axis?Phytotherapy research : PTR · 2026Review
- Review
- MIND-NL diet adherence moderates the relation of low-grade systemic inflammation with neuroinflammatory metabolites and cognitive functioning: an exploratory cross-sectional study in older adults.Journal of neuroinflammation · 2026Article
- Dietary Bioactives in Alzheimer's Disease: A Critical Appraisal of Clinical Trials and Future Nutritional Strategies.Nutrients · 2026Review
- Diet-Microbiome Relationships in Prostate-Cancer Survivors with Prior Androgen Deprivation-Therapy Exposure and Previous Exercise Intervention Enrollment.Microorganisms · 2026Article
- Liver Fibrosis and the Risks of Impaired Cognition and Dementia: Mechanisms, Evidence, and Clinical Implications.Medical sciences (Basel, Switzerland) · 2026Review
- MIND diet moderates the associations between cerebrovascular and neurodegenerative disease burden and cognition.Frontiers in nutrition · 2026Article
- Editorial: Nutrients and bioactive compounds: preventing and treating neurodegenerative diseases and disorders.Frontiers in nutrition · 2026Article
- From plate to brain: role of mediators and moderators on the impact of diet on Alzheimer's disease.Frontiers in nutrition · 2026Review
- Diet, gut microbiome, and cognition in neurodegeneration: a review and methodological framework.Frontiers in aging neuroscience · 2026Review
- Developing a QSPR model for Alzheimer's drugs using topological indices and M-polynomial: A computational study.Scientific reports · 2025Article
- The Relationship Between Diet and the Neuropathological Hallmarks of Alzheimer's Disease in Cognitively Normal Adults: A Systematic Narrative Review.Healthcare (Basel, Switzerland) · 2025Review
- Nutritional and physical pathways from feeding difficulty to sarcopenia in Alzheimer's dementia.Frontiers in nutrition · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease is a progressive neurodegenerative disorder with no cure, making preventive strategies crucial. Dietary interventions, particularly the Mediterranean (MeDi) and MIND diets, have been associated with reduced cognitive decline, but their long-term comparative effects remain underexplored. To compare the long-term neuroprotective effects of the Mediterranean and MIND diets in healthy individuals and AD patients, assess dietary adherence and cognitive function relationships, and investigate the impact of micronutrients on cognitive biomarkers. A 5-year prospective cohort study was conducted with 1500 participants (750 healthy controls, 750 AD patients). Dietary adherence was assessed using validated dietary screening tools. Cognitive function was evaluated via MMSE and MoCA scores, while biomarkers (amyloid-beta, tau, NfL, CRP, IL-6, TNF-α, polyphenols, omega-3, and B vitamins) were measured through blood and CSF samples. Machine learning techniques were utilized to analyze dietary patterns and predict cognitive trajectories. Higher adherence to both diets was associated with significantly better cognitive scores (p < 0.0001), lower amyloid-beta, tau, and NfL levels, and reduced inflammatory markers (CRP, IL-6, TNF-α). The MIND diet showed a slightly stronger association with cognitive protection than MeDi. Micronutrients such as polyphenols, omega-3, and B vitamins correlated with improved cognitive performance. Genetic analysis suggested that APOE-ε4 carriers may experience variable responses to dietary interventions. The Mediterranean and MIND diets provide significant neuroprotection against cognitive decline and AD progression. While both diets confer benefits, the MIND diet demonstrated a marginally greater impact on cognitive preservation. These findings underscore the importance of dietary interventions as non-pharmacological strategies for AD prevention and management. Further research is needed to optimize dietary recommendations based on genetic predisposition and metabolic factors.
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