Evidence map›Paper›PMID 40993183›Full record

ArticleNPJ digital medicine2025

NeoCLIP: a self-supervised foundation model for the interpretation of neonatal radiographs.

Yixuan Huang, Puneet Sharma, Anil Palepu, Nathaniel Greenbaum, Andrew Beam, Kristyn Beam

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yixuan Huang *Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Puneet Sharma *Division of Neonatology, Emory University School of Medicine, Atlanta, GA, USA.
Anil PalepuDepartment of Health Sciences & Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nathaniel GreenbaumDepartment of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Andrew BeamDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Kristyn BeamDepartment of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA, USA. kbeam@bidmc.harvard.edu.

Funding

RESEARCH TRAINING-MEDICAL INFORMATICS 90T15LM007092 · NLM · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Nils Gehlenborg · 1992 to 2026
$32.8M
The Training Program in Reproductive, Perinatal, and Pediatric Life Course EpidemiologyT32HD104612 · NICHD · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Sonia Hernandez-Diaz, Henning Tiemeier · 2021 to 2026
$2.2M
National Institute of Child Health and Human Development 5T32HD104612-03NICHD NIH HHS T32 HD104612NIH National Library of Medicine Biomedical Informatics and Data Science Research Training Program T15LM007092-30NLM NIH HHS T15 LM007092
6 · The paper itself

Abstract

Deep learning has proven to be an excellent tool for interpreting medical images in adults and children. However, it is still underdeveloped for neonates. This study developed NeoCLIP, a novel deep contrastive learning model designed to detect pathologies and medical devices on neonatal radiographs. We retrospectively studied 4629 infants admitted to a neonatal intensive care unit in Boston, MA (2008-2023), compiling 20,154 radiographs and 15,795 corresponding reports. The cohort was randomized into training (80%), validation (10%), and test (10%) sets. NeoCLIP was trained to identify 15 radiological features and 5 medical devices relevant to neonatal intensive care. NeoCLIP achieved higher AUROC compared to controls in all labels except portal venous gas. Incorporating demographic data improved model performance, though not statistically significantly. NeoCLIP is the first deep learning model tailored for the interpretation of neonatal radiographs, surpassing the efficacy of comparable adult models.

Identifiers

PMID40993183
PMCPMC12460598

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.