Evidence map›Paper›PMID 40993150›Full record

ArticleNature communications2025

Role of the real first interface in regulating ionic signal of nanochannels.

Meihua Lin, Jing Zhao, Xiaoqing Yi, Yuling Xiao, Zhiwei Shang, Lei Xu, Xin Lei, Jing Pan, Yu Huang, Xiaojin Zhang and 1 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Meihua LinState Key Laboratory of Geomicrobiology and Environmental Changes, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, China.
Jing ZhaoState Key Laboratory of Geomicrobiology and Environmental Changes, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, China.
Xiaoqing YiKey Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, China.
Yuling XiaoState Key Laboratory of Geomicrobiology and Environmental Changes, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, China.
Zhiwei ShangState Key Laboratory of Geomicrobiology and Environmental Changes, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, China.
Lei XuState Key Laboratory of Geomicrobiology and Environmental Changes, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, China.
Xin LeiKey Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry, Beihang University, Beijing, China.
Jing PanState Key Laboratory of Geomicrobiology and Environmental Changes, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, China.
Yu HuangState Key Laboratory of Geomicrobiology and Environmental Changes, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, China. yuhuang@cug.edu.cn.ORCID http://orcid.org/0000-0001-9981-2823
Xiaojin ZhangState Key Laboratory of Geomicrobiology and Environmental Changes, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, China.ORCID http://orcid.org/0000-0001-6624-2377
Fan XiaState Key Laboratory of Geomicrobiology and Environmental Changes, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, China. xiafan@cug.edu.cn.ORCID http://orcid.org/0000-0001-7705-4638

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22090050
6 · The paper itself

Abstract

Mass transport through nanochannels involves interactions across six distinct regions, including the "real first interface" (RFI), a region formed by functional elements extending into the bulk solution and their surrounding bulk solution. While previous studies have revealed the roles of the bulk solution, outer surface, and inner wall, the contribution of RFI remains unclear due to its susceptibility to interference from neighboring regions, which makes its individual role difficult to isolate. Herein, we show that a diblock DNA probe can be used to independently investigate the RFI by keeping the properties of the other five regions constant. Our results demonstrate that the RFI's role in regulating ionic current in our system is mainly determined by charge effects. These findings highlight the distinct and previously underappreciated role of the RFI in nanochannel transport and suggest that resolving its function may provide the final piece in understanding ion transport mechanisms in confined systems.

Identifiers

PMID40993150
PMCPMC12460672

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.