Evidence map›Paper›PMID 40993126›Full record

SynthesisNature communications2025

Musical rhythm abilities and risk for developmental speech-language problems and disorders: epidemiological and polygenic associations.

Srishti Nayak, Enikő Ladányi, Else Eising, Yasmina Mekki, Rachana Nitin, Catherine T Bush, Daniel E Gustavson, Manuel Anglada-Tort, Hope S Lancaster, Miriam A Mosing and 5 more

Abstract readMeta-Analysis
In one paragraph

Synthesis in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Distinct Rhythmic Competencies Identified via Internet-Based Assessment.Annals of the New York Academy of Sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Srishti NayakDepartment of Otolaryngology - Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, USA. srishti.nayak@vumc.org.ORCID http://orcid.org/0000-0001-6581-3510
Enikő LadányiDepartment of Otolaryngology - Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Else EisingLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-9819-1260
Yasmina MekkiDepartment of Otolaryngology - Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Rachana NitinDepartment of Otolaryngology - Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Catherine T BushDepartment of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-0821-3388
Daniel E GustavsonInstitute for Behavioral Genetics, University of Colorado, Boulder, Boulder, CO, USA.ORCID http://orcid.org/0000-0002-1470-4928
Manuel Anglada-TortDepartment of Psychology, Goldsmiths, University of London, London, UK.ORCID http://orcid.org/0000-0003-3421-9361
Hope S LancasterCenter for Childhood Deafness, Language, and Learning, Boys Town National Research Hospital, Omaha, NE, USA.ORCID http://orcid.org/0000-0001-9924-9508
Miriam A MosingDepartment of Cognitive Neuropsychology, Max Planck Institute for Empirical Aesthetics, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0003-2049-125X
Fredrik UllénDepartment of Cognitive Neuropsychology, Max Planck Institute for Empirical Aesthetics, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0002-2974-9256
Cyrille L MagnePsychology Department, Middle Tennessee State University, Murfreesboro, TN, USA.ORCID http://orcid.org/0000-0003-4943-9244
Simon E FisherLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-3132-1996
Nori JacobyDepartment of Psychology, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0003-2868-0100
Reyna L GordonDepartment of Otolaryngology - Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, USA. reyna.gordon@alumni.usc.edu.

Funding

ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7M
ABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5M
Adolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5M
ABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7M
Prospective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2M
ABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7M
ABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9M
FIU-ABCD: Pathways and Mechanisms to Addiction in the Latino Youth of South FloridaU01DA041156 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI Raul Gonzalez, Angela R Laird · 2015 to 2026
$22.8M
ABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3M
ABCD-USA: NYC Research ProjectU01DA041174 · NIDA · YALE UNIVERSITY · PI Arielle Ryan Baskin-Sommers, Betty J Casey · 2015 to 2026
$19.7M
Adolescent Brain Cognitive Development (ABCD) Prospective Research in Studies of Maturation (PRISM) ConsortiumU01DA041117 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LINDA CHANG, THOMAS M ERNST · 2015 to 2026
$19.5M
15/21 ABCD-USA Consortium: Research Project Site at LIBRU01DA050989 · NIDA · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI ROBIN L AUPPERLE, MARTIN P. PAULUS · 2020 to 2026
$14.7M
NICHD NIH HHS P50 HD103537NIDA NIH HHS R01 DA059804NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U01 DA050987NIDA NIH HHS U01 DA050988NIDA NIH HHS U01 DA050989NIDA NIH HHS U01 DA051016NIDA NIH HHS U01 DA051018NIDA NIH HHS U01 DA051037NIDA NIH HHS U01 DA051038NIDA NIH HHS U01 DA051039NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147NIDCD NIH HHS R01 DC016977NIDCD NIH HHS R03 DC021550NIDCD NIH HHS R21 DC021276U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) P20GM1023U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) R01DC016977U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) R03DC021550U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) R21DC021276U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R01DA059804
6 · The paper itself

Abstract

Impaired musical rhythm abilities and developmental speech-language related disorders are biologically and clinically intertwined. Prior work examining their relationship has primarily used small samples; here, we studied associations at population-scale by conducting the largest systematic epidemiological investigation to date (total N = 39,358). Based on existing theoretical frameworks, we predicted that rhythm impairment would be a significant risk factor for speech-language disorders in the general adult population. Findings were consistent across multiple independent datasets and rhythm subskills (including beat synchronization and rhythm discrimination), and aggregate meta-analyzed data showed that non-linguistic rhythm impairment is a modest but consistent risk factor for developmental speech, language, and reading disorders (OR = 1.33 [1.18 - 1.49]; p < .0001). Further, cross-trait polygenic score analyses (total N = 7180) indicated shared genetic architecture between musical rhythm and reading abilities, suggesting genetic pleiotropy between musicality and language-related phenotypes.

Indexed as

Language Development DisordersMultifactorial InheritanceMusicAdolescentAdultFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedRisk FactorsYoung Adult

Identifiers

PMID40993126
PMCPMC12460677

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.