Evidence map›Paper›PMID 40993085›Full record

ArticleExperimental animals2026

Generation of mice expressing liver-specific fluorescent genes and the optimal conditions for signal detection via in vivo imaging.

Shuho Hori, Hideki Hayashi, Kayoko Iwao, Ayaka Nakamura, Hideaki Sumiyoshi, Yutaka Inagaki, Masato Ohtsuka, Hiromi Miura

Abstract read
In one paragraph

Article in Experimental animals, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuho HoriSupport Center for Medical Research and Education, Tokai University (currently Life Science Support Center, Tokai University), 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
Hideki HayashiSupport Center for Medical Research and Education, Tokai University (currently Life Science Support Center, Tokai University), 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
Kayoko IwaoSupport Center for Medical Research and Education, Tokai University (currently Life Science Support Center, Tokai University), 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
Ayaka NakamuraSupport Center for Medical Research and Education, Tokai University (currently Life Science Support Center, Tokai University), 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
Hideaki SumiyoshiCenter for Matrix Biology and Medicine, Graduate School of Medicine, Tokai University, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
Yutaka InagakiCenter for Matrix Biology and Medicine, Graduate School of Medicine, Tokai University, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
Masato OhtsukaThe Institute of Medical Sciences, Tokai University, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
Hiromi MiuraDepartment of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In vivo imaging enables real-time detection of excitation and emission signals and is useful for the noninvasive evaluation of temporal changes in biological tissues. The near-infrared fluorescent protein iRFP can be used for deep-tissue imaging because it emits light at wavelengths that are less attenuated by biological tissues. However, autofluorescence originating from diet, tissues, and the imaging environment can interfere with fluorescence detection; therefore, appropriate animal pretreatment and optimization of imaging conditions are essential. We generated two mouse strains: Alb

Indexed as

Gene ExpressionGreen Fluorescent ProteinsLiverLuminescent ProteinsOptical ImagingAnimalsFemaleGenes, ReporterMaleMiceMice, HairlessMice, Transgenicenhanced green fluorescent proteinGreen Fluorescent ProteinsLuminescent Proteinsenhanced green fluorescent protein (eGFP)fluorescent signalsin vivo imagingiRFP713mouse model

Identifiers

PMID40993085
PMCPMC12826568

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.