Evidence map›Paper›PMID 40992813›Full record

ArticleBritish journal of anaesthesia2025

Reanimation of rodents: an animal model for cognitive recovery from anaesthesia.

Andrew R McKinstry-Wu, Max B Kelz

Abstract readEditorial
In one paragraph

Article in British journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Andrew R McKinstry-WuDepartment of Anesthesiology & Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Neuroscience of Unconsciousness and Reanimation Research Alliance, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Chronobiology and Sleep Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Max B KelzDepartment of Anesthesiology & Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Neuroscience of Unconsciousness and Reanimation Research Alliance, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Chronobiology and Sleep Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address: kelzma@pennmedicine.upenn.edu.

Funding

Brain Wide Anesthetic-Active Neuronal NetworkR01GM151556 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Alexander Proekt · 2023 to 2026
$2.2M
Personalized Anesthesia: The Role of the Locus Coeruleus in Individual Anesthetic ResponsesR35GM142712 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MCKINSTRY-WU, ANDREW RICH · 2021 to 2025
$2.2M
Personalized Anesthetic Pharmacology Across the LifespanR01GM144377 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI KELZ, MAX · 2021 to 2024
$2.1M
NIGMS NIH HHS R01 GM144377NIGMS NIH HHS R01 GM151556NIGMS NIH HHS R35 GM142712
6 · The paper itself

Abstract

Outside of the specialty, there is often a simplified perception that anaesthesiology focuses solely on inducing and maintaining an anaesthetised state. However, patients and their families never seek a one-way trip into the abyss of general anaesthesia, a point emphasised by a senior colleague who quipped, 'any fool can put someone to sleep, it's being able to wake them up again that's important'. When emergence goes awry, in the best cases, it manifests as a mere temporal delay to normal wakefulness. However, aberrant emergence can portend underlying neuropathology including emergence and postoperative delirium, delayed neurocognitive recovery, and postoperative neurocognitive disorder. With unclear causal links between abnormal patterns of emergence and long-term outcomes, unravelling the basic neurobiology of emergence and the range of normal variability is paramount.

Indexed as

Anesthesia, GeneralAnesthesia Recovery PeriodCognitionDelayed Emergence from AnesthesiaAnimalsEmergence DeliriumHumansModels, AnimalRodentiacognitive recoverydeliriumemergence variabilitypreclinical models of emergencereanimationrighting reflex

Identifiers

PMID40992813
PMCPMC12674062

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.