Evidence map›Paper›PMID 40992796›Full record

Observational studyOpen heart2025

Triglyceride-Glucose Index: a novel prognostic predictor for postoperative cerebral infarction in off-pump coronary artery bypass grafting - insights from a nationwide multicentre study.

Shipan Wang, Yilin Li, Hao Han, Tianxu Han, Zhiran Yang, Youjin Li, Haiping Yang, Hongli Li, Gang Liu, Minjia Zhu and 8 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Open heart, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Shipan Wang *Department of Cardiac Surgery, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing, Beijing, China.
Yilin Li *Department of Cardiac Surgery, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing, Beijing, China.
Hao HanDepartment of Cardiac Surgery, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing, Beijing, China.
Tianxu HanDepartment of Cardiac Surgery, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing, Beijing, China.
Zhiran YangDepartment of Cardiac Surgery, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing, Beijing, China.
Youjin LiDepartment of Cardiac Macrovascular Surgery, People's Hospital of Ningxia Hui Autonomous Region Affiliated to Ningxia Medical University, Yinchuan, Ningxia, China.
Haiping YangDepartment of Cardiac Surgery, Capital Medical University, Beijing, China.
Hongli LiDepartment of Cardiac Surgery, Xuanwu Hospital of Capital Medical University, Beijing, China.
Gang LiuHeart Centre of The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Minjia ZhuTianjin University, Tianjin, China.
Jian HuangCardiovascular Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
Qingwu ZhaoDepartment of Cardiothoracic Surgery, Guangdong Provincial Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Jihong LiuCardiovascular Surgery, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China.
Haibin LiMedical Research Center, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing, Beijing, China.
Shuaitong ZhangSchool of Medical Technology, Beijing Institute of Technology, Beijing, China.
Yuan XueDepartment of Cardiac Surgery, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing, Beijing, China lihaiyang@mail.ccmu.edu.cn xueyuan@mail.ccmu.edu.cn zhanghongjia722@ccmu.edu.cn.
Hongjia ZhangDepartment of Cardiac Surgery, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing, Beijing, China lihaiyang@mail.ccmu.edu.cn xueyuan@mail.ccmu.edu.cn zhanghongjia722@ccmu.edu.cn.
Haiyang LiDepartment of Cardiac Surgery, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing, Beijing, China lihaiyang@mail.ccmu.edu.cn xueyuan@mail.ccmu.edu.cn zhanghongjia722@ccmu.edu.cn.ORCID http://orcid.org/0000-0003-0680-4133

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative cerebral infarction following coronary artery bypass grafting (CABG) for multivessel coronary artery disease (CAD) is a major complication and is associated with insulin resistance (IR). This study used the Triglyceride-Glucose (TyG) Index, a robust indicator of IR, to assess its association with cerebral infarction and other adverse events in patients with off-pump CABG (OPCABG).

methodsThis retrospective observational study included 3654 CAD cases from eight centres across China. The primary outcome was postoperative cerebral infarction. The predictive role of the TyG Index was evaluated using multivariate logistic regression and restricted cubic spline regression. Receiver operating characteristics analysis was conducted to assess its impact on model performance.

resultsA total of 89 patients experienced postoperative cerebral infarction. After adjusting for confounding factors, the TyG Index, whether treated as a categorical variable (OR=2.23, 95% CI 1.24 to 4.02) or a continuous variable (OR=1.80, 95% CI 1.29 to 2.51), was found to be a significant independent risk factor for postoperative cerebral infarction (both p<0.001). The restricted cubic splines regression model revealed a linear dose-response association between the TyG Index and the risk of postoperative cerebral infarction (p for non-linearity=0.861). Subgroup analysis did not indicate any interactions among subgroups (p for interaction >0.05). Incorporating the TyG Index yielded a modest but statistically significant improvement in discrimination for postoperative cerebral infarction (area under the receiver operating characteristics curve 0.724 vs 0.708; p<0.001).

conclusionsIR reflected by an elevated TyG Index predicts the risk of postoperative cerebral infarction in patients undergoing OPCABG. TRIAL REGISTRATION NUMBER: Chinese Clinical Trial Registry: Chictr2400085741.

Indexed as

Blood GlucoseCerebral InfarctionCoronary Artery Bypass, Off-PumpCoronary Artery DiseasePostoperative ComplicationsTriglyceridesAgedBiomarkersChinaFemaleFollow-Up StudiesHumansIncidenceInsulin ResistanceMaleMiddle AgedBiomarkersBlood GlucoseTriglyceridesAcute Coronary SyndromeCoronary Artery BypassMetabolic SyndromeStroke

Identifiers

PMID40992796
PMCPMC12458668

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.