ArticleYonsei medical journal2025
Significant Improvement in Long-Term Survival after Liver Resection for Hepatocellular Carcinoma: Evolving Outcomes over 20 Years.
Article in Yonsei medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Antiviral Therapy and Post-Resection Outcomes in Patients With Hepatitis B Virus-Related Hepatocellular Carcinoma.Alimentary pharmacology & therapeutics · 2026Article
- Review
- Integrated clinicopathological model versus TNM for predicting survival in resected hepatocellular carcinoma: a retrospective cohort study.BMC gastroenterology · 2026Article
- Barcelona Clinic Liver Cancer strategy adherence in hepatocellular carcinoma and its influence on long-term outcomes.Journal of gastrointestinal oncology · 2026Article
- Surgical treatment of hepatocellular carcinoma: an expert consensus-based practical recommendation from the Korean Liver Cancer Association.Journal of liver cancer · 2025Article
- Surgical treatment of hepatocellular carcinoma: an expert consensus-based practical recommendation from the Korean Liver Cancer Association.Annals of surgical treatment and research · 2025Article
- Robotic Resection of Caudate Lobe Hepatocellular Carcinoma.CRSLS : MIS case reports from SLSArticle
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Authors and funding
5 authors.
Funding
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Abstract
purposeAdvanced techniques and multidisciplinary approaches have improved hepatocellular carcinoma (HCC) surgical outcomes. This study updates the long-term survival after liver resection (LR) for HCC based on over 20 years of experience. MATERIALS AND
methodsBetween 1996 and 2017, 1963 patients with HCC underwent LR. After excluding 185 patients who received preoperative therapy, 1778 treatment-naïve HCC patients were included. Clinicopathological characteristics and surgical outcomes were compared across three periods: 1 (1996-2007), 2 (2008-2012), and 3 (2013-2017). Prognostic factors for overall survival (OS) and disease-free survival (DFS) were analyzed using Cox regression analysis.
resultsRecent trends indicate increased diagnoses at older ages, number of non-B and non-C HCC cases and decreased incidence of cirrhosis. Minor, non-anatomical, and minimally invasive LR have become more prevalent. In period 3, short-term outcomes improved, as 90-day mortality decreased to 0.3% and major complications to 5.0%. Long-term outcomes improved (5-year OS: 68.1% vs. 80.7% vs. 90.5%,
conclusionRemarkable improvements in 5-year OS and DFS were observed after curative LR for HCC, particularly in period 3. Advancements in surgical outcomes, including very low short-term mortality, along with improved surgical techniques, early detection, and refined patient selection, are likely key factors in this progress.
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