Down syndrome (Trisomy 21) disease-specific human embryonic stem cell (hESC) lines, UMICHe003-A/UM152-1, UMICHe004-A/UM202-1, and UMICHe005-A/UM229-1.

Gary D Smith, Laura Keller, Ty Hergenreder, Bing Ye

Abstract read

In one paragraph

Article in Stem cell research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gary D SmithDepartments of Obstetrics and Gynecology, Physiology, and Urology, University of Michigan Medical School, Ann Arbor, MI, USA; MStem Cell Laboratories, University of Michigan, Ann Arbor, MI, USA. Electronic address: smithgd@umich.edu.

Laura KellerDepartments of Obstetrics and Gynecology, Physiology, and Urology, University of Michigan Medical School, Ann Arbor, MI, USA; MStem Cell Laboratories, University of Michigan, Ann Arbor, MI, USA.

Ty HergenrederLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

Bing YeLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.

Funding

Human Embryonic Stem Cell Models for Studying Mechanisms Underlying Changes In Inhibitory Synapses in Down SyndromeR21HD116010 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SMITH, GARY DANIEL · 2024 to 2024

$429k

NICHD NIH HHS R21 HD116010

6 · The paper itself

Abstract

Down syndrome (DS), the chromosomal disorder caused by trisomy of chromosome 21 (Tri21), presents many neurological conditions, including intellectual disability (ID), autism spectrum disorder (ASD), epilepsy, and Alzheimer's disease (AD), and is the most common genetic cause of ID worldwide. Although some human chromosome 21 (HSA21) genes have been identified as key contributors to some of these pathologies, the mechanisms that link the triplication of HSA21 genes to most DS-related diseases remain largely unknown. To facilitate the discovery of HSA21 genes that underlie DS-related pathologies, we report here the establishment of three (3) female Tri21 disease-specific human embryonic stem cell (hESC) lines in the NIH hESC registry, UM152-1, UM202-1, and UM229-1. All three Tri21-hESC lines exhibit pluripotency, the ability to differentiate into three germ layers in vitro. These lines provide new human cellular models to study DS/Tri21 disease pathogenesis.

Indexed as

Down SyndromeHuman Embryonic Stem CellsCell DifferentiationCell LineFemaleHumans

Identifiers

PMID40992248

DOI10.1016/j.scr.2025.103831

PMCPMC13659648

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.