Evidence map›Paper›PMID 40992205›Full record

ArticleInternational journal of medical informatics2026

Extracting language information from clinical notes using large language models.

Lingfei Qian, Na Hong, Yujia Zhou, Qianqian Xie, Ruey-Ling Weng, Pitchaya Chairuengjitjaras, Xinsong Du, John Lian, Gad A Marshall, Suzanne V Blackley and 7 more

Abstract read
In one paragraph

Article in International journal of medical informatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Lingfei QianDepartment of Biomedical Informatics and Data Science, Yale School of Medicine, Yale University, New Haven, CT, USA.
Na HongDepartment of Biomedical Informatics and Data Science, Yale School of Medicine, Yale University, New Haven, CT, USA.
Yujia ZhouDepartment of Biomedical Informatics and Data Science, Yale School of Medicine, Yale University, New Haven, CT, USA.
Qianqian XieDepartment of Biomedical Informatics and Data Science, Yale School of Medicine, Yale University, New Haven, CT, USA.
Ruey-Ling WengDepartment of Biomedical Informatics and Data Science, Yale School of Medicine, Yale University, New Haven, CT, USA.
Pitchaya ChairuengjitjarasDepartment of Biomedical Informatics and Data Science, Yale School of Medicine, Yale University, New Haven, CT, USA.
Xinsong DuDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
John LianDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Gad A MarshallDepartment of Neurology, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Suzanne V BlackleyDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
John Novoa-LaurentievDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Yakeel T QuirozDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Tae Youn KimBetty Irene Moore School of Nursing, University of California, Davis, Sacramento, CA, USA.
Nicole AdamsDepartment of Internal Medicine, University of California, Davis, Sacramento, CA, USA.
Michelle L DossettDepartment of Internal Medicine, University of California, Davis, Sacramento, CA, USA.
Li ZhouDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Hua XuDepartment of Biomedical Informatics and Data Science, Yale School of Medicine, Yale University, New Haven, CT, USA. Electronic address: hua.xu@yale.edu.

Funding

Leveraging Longitudinal Data and Informatics Technology to Understand the Role of Bilingualism in Cognitive Resilience, Aging and DementiaR01AG080429 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Michelle L Dossett, HUA XU · 2023 to 2026
$5.5M
NIA NIH HHS R01 AG080429
6 · The paper itself

Abstract

backgroundPatient language proficiency plays a critical role in equitable, patient-centered care and language-related clinical research. However, language information recorded in structured fields of electronic health records (EHRs) is often incomplete or inaccurate, especially in multi-institutional settings with heterogeneous documentation practices.

objectiveTo develop and evaluate a named entity recognition (NER) pipeline that accurately extracts detailed patient language status from unstructured clinical notes using large language models (LLMs), thereby enabling scalable and generalizable language information extraction.

methodsWe defined four categories of language status-fluent use, partial ability, lack of understanding, and language mentions unrelated to the patient-and annotated two datasets from Yale New Haven Hospital (YNHH) and MIMIC-III. We evaluated the performance of proprietary and open-source LLMs, including GPT-4o, LLaMA3, and BERT, under zero-shot and fine-tuning settings. Cross-site validation was conducted to assess generalizability across institutions.

resultsGPT-4o achieved F1 scores of 87 % and 82 % on YNHH and MIMIC datasets, respectively, without fine-tuning. Fine-tuned open-source models such as BERT and LLaMA3 reached comparable or superior performance when trained on sufficient annotated data. Cross-institutional evaluations confirmed that LLMs, particularly LLaMA3, exhibited stronger generalizability than traditional models. Language mentions unrelated to patient fluency remained the most challenging category across all models.

conclusionOur NER framework enables automated extraction of nuanced language information from clinical narratives with high accuracy and generalizability. This work supports large-scale, language-focused research and has practical implications for improving patient-provider communication, interpreter service allocation, and equitable healthcare delivery.

Indexed as

Data MiningElectronic Health RecordsLanguageNatural Language ProcessingHumansLarge Language ModelsCross-sites validationLarge language modelsNamed entity recognitionPatient language information

Identifiers

PMID40992205
PMCPMC12490899

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.