Evidence map›Paper›PMID 40992074›Full record

ArticleThe Journal of surgical research2025

Insights From Bone and Muscle Oxygenation Toward a More Comprehensive Model of Tissue Healing.

Yuqian Tian, Ali H Hakim, Cody P Anderson, Prateek Sharma, Al-Murtadha Al-Gahmi, Kyung-Soo Kim, Song-Young Park, Panagiotis Koutakis, Ulka Sachdev, Adina E Draghici and 3 more

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Article in The Journal of surgical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuqian TianDepartment of Surgery, University of Nebraska Medical Center, Omaha, Nebraska.
Ali H HakimDepartment of Surgery, University of Nebraska Medical Center, Omaha, Nebraska.
Cody P AndersonSchool of Health and Kinesiology, University of Nebraska at Omaha, Omaha, Nebraska.
Prateek SharmaDepartment of Surgery, University of Nebraska Medical Center, Omaha, Nebraska.
Al-Murtadha Al-GahmiDepartment of Surgery, University of Nebraska Medical Center, Omaha, Nebraska.
Kyung-Soo KimDepartment of Surgery and VA Research Service, VA Nebraska-Western Iowa Health Care System, Omaha, Nebraska.
Song-Young ParkSchool of Health and Kinesiology, University of Nebraska at Omaha, Omaha, Nebraska; Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska.
Panagiotis KoutakisDepartment of Surgery, University of Nebraska Medical Center, Omaha, Nebraska; Department of Public Health, University of West Florida, Pensacola, Florida.
Ulka SachdevDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Adina E DraghiciDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts; Cardiovascular Research Laboratory, Spaulding Hospital Cambridge, Cambridge, Massachusetts; Schoen Adams Research Institute at Spaulding Rehabilitation, Boston, Massachusetts.
Pooneh BagherDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska.
Mark A CarlsonDepartment of Surgery, University of Nebraska Medical Center, Omaha, Nebraska; Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska.
Iraklis I PipinosDepartment of Surgery, University of Nebraska Medical Center, Omaha, Nebraska; Department of Surgery and VA Research Service, VA Nebraska-Western Iowa Health Care System, Omaha, Nebraska. Electronic address: ipipinos@unmc.edu.

Funding

Using Patient-Reported Outcomes, Inflammatory Profiles, and Cardiovascular Phenogroups to Expand the Definition of Heart Failure with Preserved Ejection FractionP20GM152326 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Rebekah L. Gundry · 2024 to 2026
$10.3M
Effect of cell-based therapies on functional, hemodynamic, and histologic outcomes in a porcine model of peripheral arterial diseaseR01AG062198 · NIA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI CARLSON, MARK A, PIPINOS, IRAKLIS ILIAS · 2019 to 2023
$3.1M
MitoQ treatment of claudication: myofiber and micro-vessel pathologyR01AG077803 · NIA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Iraklis Ilias Pipinos · 2022 to 2026
$3.0M
The role of hemoglobin alpha in diabetes-related vascular dysfunctionR01HL155618 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BAGHER, POONEH · 2021 to 2025
$2.5M
NHLBI NIH HHS R01 HL155618NIA NIH HHS R01 AG062198NIA NIH HHS R01 AG077803NIGMS NIH HHS P20 GM152326
6 · The paper itself

Abstract

introductionPredicting healing after amputation and revascularization in diabetes and PAD patients with tissue loss is challenging. Current methods, like transcutaneous oximetry, only measure skin oxygenation, overlooking deeper tissues critical for wound healing. Near-infrared spectroscopy (NIRS) during postocclusive reactive hyperemia (PORH) measures muscle oxygenation under ischemic stress but does not account for bone, which is crucial in healing of complex wounds. This study employed NIRS during PORH to evaluate both bone and muscle perfusion in a swine model of hindlimb ischemia.

methodsEight Ossabaw swine underwent right hindlimb ischemia induction via endovascular coil occlusion of the right external iliac, femoral, and popliteal arteries. PORH was performed before (T0) and 4 wk after ischemia induction (T4) using a 5-min infrarenal aortic occlusion, with NIRS recording oximetry changes in bilateral gastrocnemius muscle and metatarsal bones. Data endpoints were derived in MATLAB.

resultsAt T0 (normal circulation), bone showed a smaller StO

conclusionsBone and muscle display distinct oxygenation dynamics under ischemia. Chronic ischemia attenuates metabolic and reperfusion responses in both tissues. These findings highlight bone's under-recognized role in ischemia/reperfusion events and the need for comprehensive tissue-specific oxygenation models to predict healing outcomes.

Indexed as

Bone and BonesIschemiaMuscle, SkeletalOxygenWound HealingAnimalsDisease Models, AnimalFemaleHindlimbHumansHyperemiaMaleOximetrySpectroscopy, Near-InfraredSwineOxygenDiabetic foot ulcerIschemia-reperfusion responseNear-infrared spectroscopyPeripheral artery diseasePostocclusive reactive hyperemiaTissue healingTranscutaneous oximetry

Identifiers

PMID40992074
PMCPMC12551740

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.